PMID: 7541598Jan 1, 1995Paper

New pharmacotherapeutic modalities for negative symptoms in psychosis

Acta Psychiatrica Scandinavica. Supplementum
J P Lindenmayer

Abstract

Negative symptoms in schizophrenia comprise a psychopathologic and pathophysiologic syndrome which is absent from normal mental function. Renewed interest in negative symptoms has led to the development of better measuring instruments, among which is the Positive And Negative Syndrome Scale (PANSS), which provides a way of measuring and reporting positive and negative symptoms in a balanced and convenient form. A number of strategies are being investigated for treating negative symptoms. Dopamine agonists such as levodopa, amphetamines and bromocriptine have been shown to produce improvements in negative symptoms, although good, well-controlled clinical trials are lacking. Partial dopamine agonists, such as MAR 327, are also currently under investigation and results are expected soon. Tricyclic, selective serotonin reuptake inhibitors and monoamine oxidase antidepressants appear to be able to modify negative symptoms in schizophrenia, although, once again, carefully designed trials are needed. Modification of GABAergic transmission has shown little promise, but the use of glycine to augment transmission at N-methyl-D-aspartate (NMDA) synapses suggests that the strategy may be beneficial. These results also imply that altered gl...Continue Reading

Associated Clinical Trials

References

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Citations

Feb 7, 1998·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·D J King
Aug 26, 2006·Schizophrenia Research·Brendan P MurphyPatrick D McGorry
Dec 18, 2013·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Christina A Wilson, James I Koenig
Jun 22, 2000·Medical Hypotheses·S Al-AdawiA A Al-Hussaini
Dec 10, 1999·Journal of Clinical Psychopharmacology·T JungermanE Klein

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