PMID: 8948481Nov 13, 1996Paper

New phases induced by sucrose in saturated phosphatidylethanolamines: an expanded lamellar gel phase and a cubic phase

Biochimica Et Biophysica Acta
B G TenchovG Rapp

Abstract

A new lamellar gel phase (L beta *) with expanded lamellar period was found at low temperatures in dihexadecylphosphatidylethanolamine (DHPE) and dipalmitoylphosphatidylethanolamine (DPPE) dispersions in concentrated sucrose solutions (1-2.4 M). It forms via a cooperative, relatively broad transition upon cooling of the L beta gel phase of these lipids. According to the X-ray data, the transformation between L beta and L beta * is reversible, with a temperature hysteresis of 6-10 degrees C and a transition width of about 10 degrees C. No specific volume changes and a very small heat absorption of about 0.05 kcal/mol accompany this transition. The L beta *-L beta transition temperature strongly depends on the disaccharide concentration. From a value of about 10 degrees C below the melting transition of DHPE, it drops by 25 degrees C with decrease of sucrose concentration from 2.4 M to 1 M. The low-temperature gel phase L beta * has a repeat spacing by 8-10 A larger than that of the L beta gel phase and a single symmetric 4.2 A wide-angle peak. It has been observed in 1, 1.25, 1.5 and 2.4 M solutions of sucrose, but not in 0.5 M of sucrose. The data clearly indicate that the expanded lamellar period of the L beta * phase results ...Continue Reading

Citations

Jun 6, 2002·Chemistry and Physics of Lipids·Rumiana Koynova, Martin Caffrey
Apr 20, 2001·Advanced Drug Delivery Reviews·J C ShahD M Chilukuri
Aug 23, 2011·Neuropsychiatric Disease and Treatment·Marty HinzThomas Uncini
Jun 10, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Alexandru Zabara, Raffaele Mezzenga
Jul 6, 2014·BioMed Research International·Yulin ChenShuangying Gui
Dec 16, 1998·Journal of Colloid and Interface Science·T GutberletG Rapp
Jul 11, 2006·Biophysical Journal·Boris G TenchovDavid P Siegel
Jun 12, 1997·Biochimica Et Biophysica Acta·R KoynovaG Rapp
Mar 17, 1999·Biochimica Et Biophysica Acta·B TenchovG Rapp
Oct 7, 2017·Chemistry and Physics of Lipids·Boris Tenchov, Rumiana Koynova

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