New phenylpropanoids from Bulbophyllum retusiusculum

Archives of Pharmacal Research
Yun-Shan FangZhong-Tao Ding

Abstract

Two new phenylpropanoids, retusiusines A (1) and B (2), and a pair of new phenylpropyl enantiomers, (±)-retusiusine C (3a and 3b), together with eight known compounds, dihydroconiferyl dihydro-p-coumarate (4), methyl 3-(4-hydroxyphenyl) propionate (5), 3-(4-hydroxyphenyl)-propanoic acid (6), dihydroferulic acid (7), methyl 3-(4-methoxyphenyl) propionate (8), 3-(3,4-dimethoxyphenyl)-2-propenal (9), trans-p-coumaric acid (10) and dihydroconiferyl alcohol (11), were isolated from the tubers of Bulbophyllum retusiusculum. The absolute configurations of the new compounds were determined by calculating their electronic circular dichroism (ECD), spectra and specific optical rotations and comparing the calculated values with the experimental data. Compound 2 exhibited potent antifungal activity against Candida albicans (16 μg/mL). Compound 3 showed moderate antibacterial activity against Bacillus subtilis (64 μg/mL).

References

Sep 25, 2004·Journal of Natural Products·Yuan-Wah Leong, Leslie J Harrison
Aug 11, 2010·Journal of Agricultural and Food Chemistry·Kumudini M MeepagalaStephen O Duke
Jan 6, 2016·Natural Product Research·Ming-Hui YangZhong-Tao Ding

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Citations

Oct 6, 2020·Natural Product Research·Xue-Yun CaiZhong-Tao Ding
Apr 13, 2021·Journal of Asian Natural Products Research·Feng WangZhen-Feng Fang
Apr 28, 2021·Fitoterapia·Yun-Shan FangZhong-Tao Ding

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