PMID: 8451285Feb 1, 1993Paper

New phthalocyanine photosensitizers for photodynamic therapy

Photochemistry and Photobiology
N L OleinickM E Kenney

Abstract

Six new aluminum and silicon phthalocyanines have been synthesized and their photocytotoxicity toward V79 cells has been studied. The compounds that have been prepared are: A1PcOSi(CH3)2(CH2)3N(CH3)2, I; A1Pc-OSi(CH3)2(CH2)3N(CH3)3+I-, II; CH3SiPcOSi(CH3)2(CH2)3N(CH3)2, III; HOSiPcOSi(CH3)2(CH2)3N(CH3)2, IV; HOSiPcOSi(CH3)2(CH2)3N(CH3)3+I-, V; and SiPc[OSi(CH3)2(CH2)3N(CH3)3+I-]2, VI. Relative growth delay values for compounds I-VI and relative cytotoxicity values for compounds I, II, IV, V and VI have been determined. Compounds I and II have been shown to be comparable in photocytotoxicity to what is presumed to be A1PcOH.xH2O, and compound IV has been shown to have greater activity. The classes of compounds to which these six compounds belong appear to have potential for photodynamic therapy.

References

Jan 1, 1989·Methods in Cell Biology·L B Chen
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·A R OseroffL Cincotta

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Citations

Jan 1, 1997·Lasers in Surgery and Medicine·Z SmetanaE Ben-Hur
Oct 1, 1995·Journal of the American Academy of Dermatology·J W GouldC A Elmets
Nov 16, 2013·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Racheal O Ogbodu, Tebello Nyokong
Nov 7, 2000·Journal of Inorganic Biochemistry·M E Vol'pinA A Aver'yanov
Oct 26, 1999·Drug Discovery Today·W M Sharman van Lier JE
Dec 1, 2004·Photodiagnosis and Photodynamic Therapy·R R AllisonC H Sibata
Feb 8, 2011·Journal of the American Chemical Society·Yu ChengClemens Burda
Jul 23, 2008·Journal of the American Chemical Society·Yu ChengClemens Burda
Aug 20, 2011·Chemical Communications : Chem Comm·Xianchun ZhuRuomei Gao
Apr 28, 2011·Photochemistry and Photobiology·Minh LamElma D Baron
Aug 19, 2011·Photochemistry and Photobiology·Mathias O Senge, Johan C Brandt
Jan 10, 2012·Photochemistry and Photobiology·Shalini SagguAnna-Liisa Nieminen
May 16, 2012·Photochemistry and Photobiology·Timothy M Baran, Thomas H Foster
Dec 17, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Baowei FeiSong-mao Chiu
Apr 5, 2011·The Journal of Chemical Physics·Tamara BasovaThomas Chassé
Jan 19, 2011·The Journal of Chemical Physics·Elisa I MartínEnrique Sánchez Marcos
Sep 26, 2008·Metal-based Drugs·Leanne B Josefsen, Ross W Boyle
Nov 9, 2010·Journal of Biomedical Optics·Myriam E RodriguezNancy L Oleinick
Dec 8, 2009·Journal of Pharmaceutical Sciences·Alyssa M MasterAnirban Sen Gupta
Nov 30, 2011·Seminars in Cutaneous Medicine and Surgery·Yoojin Lee, Elma D Baron
Oct 26, 2011·Nanomedicine : Nanotechnology, Biology, and Medicine·Alyssa M MasterAnirban Sen Gupta
Jun 1, 2007·Photodiagnosis and Photodynamic Therapy·Pui-Chi LoDennis K P Ng
Nov 18, 2003·Photodermatology, Photoimmunology & Photomedicine·Asako MatsuyamaKatsumi Hanada
Aug 3, 2010·Journal of Magnetic Resonance Imaging : JMRI·Hesheng Wang, Baowei Fei
May 30, 1998·IEEE Engineering in Medicine and Biology Magazine : the Quarterly Magazine of the Engineering in Medicine & Biology Society·R F PittauA Aoki
Aug 4, 2015·The Journal of Chemical Physics·Elisa I MartínEnrique Sánchez Marcos
Feb 5, 2008·Free Radical Biology & Medicine·Junhwan KimVernon E Anderson
Nov 27, 2016·Photodiagnosis and Photodynamic Therapy·Jingwen XueYuehua Liu
Oct 7, 2000·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C H SibataT J Kinsella
Mar 2, 2016·Chemistry : a European Journal·Anzhela GalstyanAndreas Faust
Oct 5, 2001·Expert Opinion on Pharmacotherapy·C H SibataT J Kinsella

❮ Previous
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