New players in cytokine control of HIV infection.

Current HIV/AIDS Reports
M AlfanoG Poli

Abstract

Cytokines are involved early in the pathogenesis of HIV infection and disease progression as a component of immunologic dysregulation and immunodeficiency and as determinants controlling virus replication. Several steps, before and after retroviral integration into host DNA in T cells and macrophages, are affected by cytokines whereas CCR5 and CXCR4 binding chemokines can interfere with viral entry. A growing number of potential players--including the gamma-common interleukin (IL)-7, IL-15, and IL-21 together with IL-17, IL-18, IL-19, IL-20, IL-23, and IL-27--are discussed in terms of their perturbation in HIV infection and of their effects on virus replication. Thus, an increasing intersection of HIV infection and the cytokine network represents a crucial determinant of virus replication and immunologic dysregulation and will likely play a key role in the development of effective strategies of HIV prevention and immunologic reconstitution.

References

Oct 15, 1998·Proceedings of the National Academy of Sciences of the United States of America·L ShapiroC A Dinarello
Mar 29, 2002·The Journal of Infectious Diseases·Donato TorreRoberto Tambini
Oct 24, 2002·Blood·Yvonne M MuellerPeter D Katsikis
Apr 21, 2004·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Birgitte LindegaardBente Klarlund Pedersen
Sep 9, 2004·AIDS·Birgitte LindegaardBente Klarlund Pedersen
Oct 19, 2004·Molecular Immunology·Massimo Alfano, Guido Poli
Nov 24, 2004·Microbes and Infection·Alicja Wiercinska-DrapaloDanuta Prokopowicz
Jan 5, 2005·The Journal of Experimental Medicine·Rong ZengWarren J Leonard
May 25, 2005·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Julieta KopkaLuisa Sen
Sep 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Annette AudigéRoberto F Speck
Apr 15, 2006·Journal of Leukocyte Biology·Mingjie ZhangAndrew I Dayton
May 17, 2006·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·C TorneroD Navarro
Jun 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elizabeth BolestaDanuta Kozbor
Jan 26, 2007·The Journal of General Virology·Annette R RodriguezKrishna K Murthy
Feb 8, 2007·Proceedings of the National Academy of Sciences of the United States of America·Lia VassenaPaolo Lusso
Feb 13, 2007·Annual Review of Immunology·Robert A KasteleinDaniel J Cua
Mar 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anna HryniewiczGenoveffa Franchini
May 1, 2007·Expert Opinion on Therapeutic Targets·Robert SabatKerstin Wolk
May 19, 2007·Cytokine & Growth Factor Reviews·Katja BrandtRené Rückert
Sep 4, 2007·Current Opinion in Immunology·Estelle BettelliVijay K Kuchroo

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Citations

Apr 14, 2010·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Sonia ShahBrian Wigdahl
Sep 29, 2011·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Govardhana Rao YannamLarisa Y Poluektova
Feb 11, 2009·The Journal of Experimental Medicine·Wanqiu HouByung S Kim
Apr 9, 2010·Retrovirology·Anna Bergamaschi, Gianfranco Pancino
Apr 13, 2010·Retrovirology·Georges Herbein, Audrey Varin
Jun 16, 2010·Retrovirology·Rafael Van den BerghGeert Raes
Nov 10, 2009·Veterinary Immunology and Immunopathology·Mauro PistelloGiulia Freer
May 30, 2009·Journal of Medical Primatology·Nattawan Promadej-LanierRon A Otten
Jan 13, 2011·American Journal of Reproductive Immunology : AJRI·Melanie MerbahLeonid Margolis
Jun 3, 2016·Scientific Reports·Daria TrabattoniMario Clerici
Jul 23, 2016·Journal of Immunology Research·Igor Z BarjaktarevicRobert J Kaner
Aug 23, 2011·AIDS·Appakkudal R AnandRamesh K Ganju
Jun 2, 2017·The Open Virology Journal·S PasquereauG Herbein
May 19, 2018·International Journal of Molecular Sciences·Manuel Delgado-Vélez, José A Lasalde-Dominicci
Jan 1, 2010·Journal of Leukocyte Biology·Edana CassolGuido Poli
Apr 29, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anthony J SmithAshley T Haase
Jan 12, 2019·Journal of Cellular and Molecular Medicine·Xiao-Xia PangJun-Li Wang
Jun 24, 2016·Journal of Virology·Aaron Christensen-QuickAlfredo Garzino-Demo

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