New Players in the Same Old Game: Disturbance of Group 2 Innate Lymphoid Cells in HIV-1 and Mycobacterium leprae Co-infected Patients

PLoS Neglected Tropical Diseases
Pedro Henrique PapottoKarina Inácio Carvalho

Abstract

Leprosy control is achieved through a fine-tuning of TH1 and TH2 immune response pattern balance. Given the increasing epidemiological overlay of HIV and M. leprae infections, immune response in co-infected patients consists in an important contemporary issue. Here we describe for the first time the innate lymphoid cells compartment in peripheral blood of leprosy and HIV/M. leprae co-infected patients, and show that co-infection increases group 2 innate lymphoid whilst decreasing group 1 innate lymphoid cells frequencies and function.

References

Oct 2, 2001·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Z ToossiC S Hirsch
Jun 19, 2004·BMJ : British Medical Journal·Diana N J Lockwood, Bhushan Kumar
May 27, 2006·The Lancet Infectious Diseases·Andrew P UstianowskiDiana N J Lockwood
Jan 26, 2013·Nature Reviews. Immunology·Hergen SpitsEric Vivier
Nov 23, 2013·European Journal of Microbiology & Immunology·Andreas Diefenbach
Dec 24, 2013·Transactions of the Royal Society of Tropical Medicine and Hygiene·Vinicius M MenezesMariana A Hacker

❮ Previous
Next ❯

Citations

Jun 27, 2017·The Journal of Clinical Investigation·Mathieu F ChevalierLaurent Derré

❮ Previous
Next ❯

Methods Mentioned

BETA
flow cytometry

Software Mentioned

FlowJo
FACSDiva

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

Acta Pathologica Et Microbiologica Scandinavica. Section B: Microbiology and Immunology
B MyrvangD R Samuel
International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association
T GodalK Negassi
Transactions of the Royal Society of Tropical Medicine and Hygiene
Vinicius M MenezesMariana A Hacker
© 2021 Meta ULC. All rights reserved