New PMMA-based composites for preparing spacer devices in prosthetic infections.

Journal of Materials Science. Materials in Medicine
Gianluca GiavaresiMilena Fini

Abstract

Even though the systemic antibiotic therapy is usually applied after prosthetic infections surgical treatments, it is unable to reach the infection site in sufficient concentrations to eradicate bacteria. Delivering antibiotics locally with the use of custom made device (spacer or nail coating) might eradicate or reduce the infection and the risk of recolonization, providing a very high concentration of antibiotic. PMMA-based (Mendec Spine) composites with BaSO(4) were enriched with β-tricalcium phosphate (Porosectan-TCP) or only a slightly higher BaSO(4) concentration (Porosectan-BaSO(4)) to obtain higher porosity. The aim of the study was to evaluate: (i) drug absorption capability and drug release kinetics in vitro soaking them with a combined solution of gentamicin and vancomycin, (ii) their in vitro and in vivo biocompatibility, and finally, (iii) they were tested preliminarily in an experimental model of bone infection. The simultaneous presence of β-TCP and BaSO(4) resulted in the formation of a texture of interconnecting channels with different diameters, from a few microns to several hundred microns, which totally filled the material. The porosity, determined by microcomputed tomography, was significantly higher in bot...Continue Reading

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Citations

Dec 24, 2013·International Orthopaedics·Gianluca GiavaresiCarlo L Romanò
Mar 16, 2019·Journal of Medical Microbiology·Marta BottagisioArianna B Lovati
Jan 7, 2021·Biomedicines·Victoria WallPhong A Tran
Sep 4, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Cristian GuariseMilena Fini
Nov 11, 2021·Drug Delivery·Reem Khaled WassifSeham A Elkheshen

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