New PMMA-co-EHA glass-filled composites for biomedical applications: Mechanical properties and bioactivity

Acta Biomaterialia
P P LopesRui Correia

Abstract

A bioactive glass of the 3CaO.P(2)O(5)-MgO-SiO(2) system was incorporated as a filler into poly(methylmethacrylate)-co-(ethylhexylacrylate) (PMMA-co-EHA) copolymer. The effect of filler proportion (0, 30, 40 and 50wt.%) on the bending properties was evaluated and a maximum flexural strength of 29MPa coupled with an elastic modulus of 1.1GPa was obtained at an intermediate filler concentration (30wt.%). These values are slightly higher than those usually reported for human cancellous bone. The in vitro bioactivity was assessed by determining the changes in surface morphology and composition after soaking in simulated body fluid (SBF, Kokubo solution). Inductively coupled plasma was used to trace the evolution of ionic concentrations in the SBF solution, namely Ca and P. X-ray diffraction and scanning electron microscopy confirmed the growth of spherical calcium phosphate aggregates on the surface of composites, indicating that the composites are potentially bioactive.

Citations

May 11, 2011·Journal of Materials Science. Materials in Medicine·P P LopesM H V Fernandes
Dec 18, 2012·Journal of Materials Science. Materials in Medicine·Charlie R CampionKarin A Hing
Jun 26, 2015·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Gabriel FurtosMaria Tomoaia-Cotisel
Jun 27, 2012·Journal of Biomedical Materials Research. Part a·Govinda KapusettiPralay Maiti
Aug 3, 2013·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Lizette Morejón AlonsoMaria-Pau Ginebra
Sep 12, 2014·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·E Franco-MarquèsJ A Méndez
Jul 7, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Govinda KapusettiPralay Maiti
Aug 25, 2012·Journal of Biomaterials Applications·P LopesM H V Fernandes
May 7, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Govinda KapusettiPralay Maiti
Jul 17, 2012·Journal of Applied Biomaterials & Functional Materials·Bárbara J M Leite FerreiraRui Nunes Correia

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