New probiotic strains for inflammatory bowel disease management identified by combining in vitro and in vivo approaches

Beneficial Microbes
J AlardC Grangette

Abstract

Alterations in the gut microbiota composition play a key role in the development of chronic diseases such as inflammatory bowel disease (IBD). The potential use of probiotics therefore gained attention, although outcomes were sometimes conflicting and results largely strain-dependent. The present study aimed to identify new probiotic strains that have a high potential for the management of this type of pathologies. Strains were selected from a large collection by combining different in vitro and in vivo approaches, addressing both anti-inflammatory potential and ability to improve the gut barrier function. We identified six strains with an interesting anti-inflammatory profile on peripheral blood mononuclear cells and with the ability to restore the gut barrier using a gut permeability model based on Caco-2 cells sensitized with hydrogen peroxide. The in vivo evaluation in two 2,4,6-trinitrobenzene sulfonic acid-induced murine models of colitis highlighted that some of the strains exhibited beneficial activities against acute colitis while others improved chronic colitis. Bifidobacterium bifidum PI22, the strain that exhibited the most protective capacities against acute colitis was only slightly efficacious against chronic col...Continue Reading

References

Jan 10, 2002·Gastroenterology·Alexander SwidsinskiHerbert Lochs
Jan 18, 2007·World Journal of Gastroenterology : WJG·Benoit FoligneBruno Pot
Mar 22, 2007·PloS One·Benoit FoligneCorinne Grangette
Feb 23, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·A SethR K Rao
Oct 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·Harry SokolPhilippe Langella
Mar 17, 2011·Nature Reviews. Microbiology·Aymé SporRuth Ley
Jun 18, 2011·Pathology Oncology Research : POR·Laszlo BeneAndras Kristof Fulop
Sep 14, 2012·Journal of Clinical Gastroenterology·Giovanni BarbaraVincenzo Stanghellini
Jan 5, 2013·Current Opinion in Gastroenterology·Kevin Whelan, Eamonn M M Quigley
Jan 6, 2016·Applied and Environmental Microbiology·Elodie NeauAnne-Judith Waligora-Dupriet
Oct 1, 2016·Scandinavian Journal of Gastroenterology·Michelle ProsbergLise L Gluud
Oct 13, 2016·Gastroenterology·Thaddeus S Stappenbeck, Dermot P B McGovern

❮ Previous
Next ❯

Citations

Feb 6, 2019·Nutrients·Sheila Estruel-AmadesMariona Camps-Bossacoma
Jan 10, 2019·Frontiers in Microbiology·Aurélie MaurasAnne-Judith Waligora-Dupriet
May 15, 2018·Xenotransplantation·Robin A Weiss
Feb 2, 2020·Digestive Diseases and Sciences·Akihiko Oka, R Balfour Sartor
Nov 12, 2019·Frontiers in Pediatrics·Yue SunHailong Cao
Apr 4, 2021·Microorganisms·Bernardo CuffaroEmmanuelle Maguin
May 11, 2021·MicrobiologyOpen·Brenda Maldonado-ArriagaGraciela Castro-Escarpulli
Dec 11, 2021·Applied Microbiology and Biotechnology·M Guerrero SanchezF Fonseca

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.