New prospects on the NKG2D/NKG2DL system for oncology

Oncoimmunology
Evelyn UllrichAlexander Steinle

Abstract

The activating immunoreceptor NKG2D endows cytotoxic lymphocytes with the capacity to recognize and eliminate infected or malignant cells. The recognition of such harmful cells is enabled by binding of NKG2D to various MHC class I-related glycoproteins, which are upregulated in the course of viral infection or malignant transformation. The past years have witnessed substantial progress in our understanding of the mechanisms underlying the regulation of NKG2D ligands (NKG2DLs) by malignant cells, of tumor-associated countermeasures promoting escape from NKG2D-dependent immunosurveillance, and of therapeutic measures that may bolster the NKG2D/NKG2DL system against malignancies. Here, we summarize the current knowledge on the NKG2D/NKG2DL system and outline opportunities to exploit the tumoricidal function of NKG2D for anticancer immunotherapy.

References

Oct 29, 1996·Proceedings of the National Academy of Sciences of the United States of America·V GrohT Spies
Jun 9, 1999·Proceedings of the National Academy of Sciences of the United States of America·V GrohT Spies
Sep 20, 2001·Proceedings of the National Academy of Sciences of the United States of America·A CerwenkaL L Lanier
Oct 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Helmut R SalihAlexander Steinle
Nov 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yoshihiro HayakawaMark J Smyth
Nov 12, 2002·Nature Immunology·Susan GilfillanMarco Colonna
Apr 2, 2003·Nature Reviews. Immunology·Wayne M Yokoyama, Beatrice F M Plougastel
May 13, 2003·Nature Immunology·Simona ZompiFrancesco Colucci
Jul 25, 2003·Proceedings of the National Academy of Sciences of the United States of America·Veronika GrohThomas Spies
Oct 3, 2003·Nature Reviews. Immunology·David H Raulet
Dec 21, 2004·Nature Reviews. Microbiology·Melissa B Lodoen, Lewis L Lanier
Mar 18, 2005·Annual Review of Immunology·Lewis L Lanier
May 14, 2005·Blood·Tong ZhangCharles L Sentman
May 17, 2005·Proceedings of the National Academy of Sciences of the United States of America·David GarrityKai W Wucherpfennig
Jul 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Katrin WiemannAlexander Steinle
Aug 6, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bladimiro Rincon-OrozcoThomas Herrmann
Sep 1, 2005·The Journal of Experimental Medicine·Mark J SmythYoshihiro Hayakawa
May 4, 2006·Rehabilitation Nursing : the Official Journal of the Association of Rehabilitation Nurses·Patrice K NicholasSusan Cross-Skinner
May 6, 2006·Seminars in Immunology·Yoshihiro Hayakawa, Mark J Smyth
Aug 18, 2006·Seminars in Cancer Biology·Stephan Gasser, David Raulet
Mar 14, 2007·FEBS Letters·Henry OgbomoJindrich Cinatl
Aug 4, 2007·Nature Reviews. Immunology·Robert A Eagle, John Trowsdale

❮ Previous
Next ❯

Citations

Dec 7, 2013·Cellular and Molecular Life Sciences : CMLS·Janina Binici, Joachim Koch
Dec 5, 2015·Frontiers in Immunology·Benedikt JacobsEvelyn Ullrich
Jul 30, 2014·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Mee Rie SheenSteven Fiering
May 28, 2015·Immunologic Research·Laura S AngeloJordan S Orange
May 30, 2015·Biochemical and Biophysical Research Communications·Chen YanGong Weijuan
May 3, 2015·BMC Cancer·Ariane GiannattasioJoachim Koch
Jul 23, 2014·Oncoimmunology·Aroa Baragaño RanerosCarlos López-Larrea
Apr 14, 2015·Cellular & Molecular Immunology·Mateusz LegutAndrew K Sewell
Oct 2, 2014·Journal of Gastroenterology·Kaku Goto, Naoya Kato
Jun 21, 2016·Expert Opinion on Therapeutic Targets·Alma Chávez-BlancoAlfonso Duenas-Gonzalez
Sep 27, 2016·Trends in Immunology·Rosa MolfettaRossella Paolini
Jan 28, 2017·Nature Communications·Sam SheppardNadia Guerra
May 13, 2017·Nature Reviews. Neurology·Michael WellerJohn H Sampson
Feb 22, 2017·Scientific Reports·Michael SunTo-Ha Thai
Sep 21, 2017·International Journal of Molecular Sciences·Kasper Vadstrup, Flemming Bendtsen
Aug 3, 2017·International Journal of Molecular Sciences·Rosa MolfettaRossella Paolini
Jan 9, 2018·Oncoimmunology·Stefanie MaurerHelmut Rainer Salih
Jul 8, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sebastian NeussAlexander Steinle
Sep 22, 2016·Nature Communications·Reza GhasemiAlexander Sasha Krupnick
Feb 9, 2019·Expert Opinion on Therapeutic Targets·Mariya Lazarova, Alexander Steinle
Apr 4, 2015·Science·Alexander Steinle, Adelheid Cerwenka
Apr 13, 2018·The EMBO Journal·Da LinChristopher A O'Callaghan
Jul 30, 2020·Expert Opinion on Biological Therapy·Mariya LazarovaAlexander Steinle
Jul 3, 2015·Journal of Leukocyte Biology·Simone BattellaGabriella Palmieri
Apr 6, 2017·Frontiers in Immunology·Fabio E LealLishomwa C Ndhlovu
Nov 29, 2016·Frontiers in Immunology·Maxim Shevtsov, Gabriele Multhoff
Sep 6, 2018·Neuromolecular Medicine·Wanli YuChunzhi Zhang
Sep 14, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stefanie RaabHelmut R Salih

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Immunology
Robert A EagleJohn Trowsdale
Trends in Molecular Medicine
Carlos López-LarreaSegundo González
Oncogene
Inja Waldhauer, Alexander Steinle
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Annette PaschenSelma Ugurel
Trends in Immunology
Segundo GonzálezCarlos López-Larrea
© 2021 Meta ULC. All rights reserved