New psychiatric and psychological aspects of diagnosis and treatment of hepatitis C and relevance for opiate dependence

Current Opinion in Psychiatry
Jens ReimerChristian Haasen

Abstract

This review highlights the aspects of the hepatitis C virus that are important to the psychiatrist. Hepatitis C virus infection is frequently associated with mental clouding, depression, neurocognitive impairment, and deterioration in the quality of life. In recent studies psychiatric symptoms have been linked to psychiatric comorbidity rather than to direct hepatitis C virus neurotoxicity. Infection of the central nervous system, however, is thought to play a role at least in hepatitis C virus associated neurocognitive deficits. Application of the anti-hepatitis C virus agent interferon-alpha is regularly accompanied by psychiatric symptoms, most often depression. Antidepressant treatment may support interferon therapy, but its general indication and timing remain debatable. The problem of hepatitis C virus treatment in manic patients is still unsolved. Hepatitis C infection rates in injection drug users are often 90% and higher, while these patients in particular face barriers when trying to access treatment. Recent studies demonstrated feasibility of hepatitis C virus treatment in injection drug users in specialized treatment settings. Hepatitis C virus infection is associated with psychiatric comorbidity and injection drug ...Continue Reading

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Citations

Nov 6, 2008·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·B SchulteJ Reimer
Aug 11, 2012·Journal of Hepatology·Martin SchaeferCarmine M Pariante

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