New pyrazinoquinazoline alkaloids Isolated from a culture of Stenotrophomonas maltophilia QB-77

Natural Product Research
Sheng-Yan QianGui-Guang Cheng

Abstract

Two new pyrazinoquinazoline alkaloids, epi-fiscalin D (1) and epi-fiscalin E (2), as well as three known analogues, norquinadoline A (3), quinadoline A (4), and fiscalin C (5), were isolated from ethyl acetate extract of the fermentation broth of Stentrophomonas maltophilia QB-77. The structures of new compounds were elucidated on the basis of extensive spectroscopic data analysis including UV, HRESIMS, and 1D and 2D NMR experiments. All the isolated compounds were tested for their in vitro cytotoxicity against five human cancer cell lines (SMMC-7721, MCF-7, HL-60, SW480, and A-549) and antibacterial activities against Bacillus subtilis, Escherichia coli, and Staphylococcus aureus.

References

Jan 21, 1977·The Journal of Organic Chemistry·G BüchiJ M Townsend
Feb 20, 2013·Journal of Asian Natural Products Research·De-Lan YangHao-Fu Dai
Jun 14, 2013·Journal of Natural Products·Jixing PengDehai Li
Aug 16, 2013·Journal of Natural Products·Mei-Fen BaoXiao-Dong Luo
Jun 21, 2014·Natural Product Research·Tian-Peng YinZhong-Tao Ding
Mar 5, 2015·Natural Product Research·Sasiphimol SawadsitangSirirath Sodngam
Jul 15, 2015·Natural Product Research·Pham Bich NgocTien Dat Nguyen
Mar 8, 2016·Journal of Asian Natural Products Research·Shi-Ji XiaoYan Zhou
Mar 19, 2016·Journal of Asian Natural Products Research·Xiao AnYue-Hu Pei
Jun 2, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yuhong LüYing Huang
Oct 1, 2016·Natural Product Research·Magdy M D Mohammed, Eman R El-Sharkawy
Dec 10, 2016·Natural Product Research·Fei GaoGui-Guang Cheng
Jan 10, 2017·Natural Product Research·Qing-Long LiuWei Xu
Feb 18, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yuhong LüYonglin Hu
Apr 1, 2017·Natural Product Research·Zong WanGui-Guang Cheng

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Citations

Dec 12, 2019·Journal of Natural Products·Fan-Dong KongYou-Xing Zhao

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Methods Mentioned

BETA
NMR

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