New quinolone antibiotics: a survey of the literature from 2005 to 2010

Expert Opinion on Therapeutic Patents
Jason A WilesMichael J Pucci

Abstract

The quinolone class of antibacterial agents has a proven track record over the past several decades for the treatment of bacterial infections. Their unique mechanism of action and bactericidal properties make them attractive therapeutic agents. Significant research efforts continue to the present day in both academia and industry, which have provided a number of promising drug candidates for further development. This review examines quinolones that have been approved for market, entered into clinical trials or reported in the literature during 2005 - 2010. The reader will be provided with background information on the quinolones as well as recent research findings that demonstrate the continued utility of the class as antibacterial agents. The review highlights a number of recently reported compounds of interest. Despite nearly 40 years of research, quinolones still provide new analogs of both scientific and clinical interest. Compounds that are active against antibiotic resistant strains including multiple drug-resistant Mycobacterium tuberculosis as well as compounds with improved pharmacokinetic and safety profiles are goals for current and future programs in this area.

References

Feb 1, 1989·Antimicrobial Agents and Chemotherapy·D T Chu, P B Fernandes
Jun 1, 1988·Antimicrobial Agents and Chemotherapy·K FujimakiS Mitsuhashi
Dec 1, 1993·Antimicrobial Agents and Chemotherapy·S A Marshall, R N Jones
Jun 22, 2000·Medicinal Research Reviews·Q LiL L Shen
Nov 18, 2000·Antimicrobial Agents and Chemotherapy·J C Fung-TomcD P Bonner
Feb 28, 2002·The Journal of Antimicrobial Chemotherapy·Tetsumi YamakawaKazuya Hayashi
Apr 19, 2003·The Journal of Antimicrobial Chemotherapy·A M Emmerson, A M Jones
Nov 19, 2003·Bioorganic & Medicinal Chemistry Letters·Mikhail F GordeevDinesh V Patel
Apr 2, 2004·The Journal of Antimicrobial Chemotherapy·S J HarnettR Wise
Mar 23, 2005·Bioorganic & Medicinal Chemistry Letters·Anand V Shindikar, C L Viswanathan
May 25, 2005·Bioorganic & Medicinal Chemistry·Yue-Ling ZhaoCherng-Chyi Tzeng
Jun 9, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Robert C Owens, Paul G Ambrose
Jul 29, 2005·Antimicrobial Agents and Chemotherapy·Tatiana BogdanovichPeter C Appelbaum
Aug 24, 2005·Bioorganic & Medicinal Chemistry Letters·Dharmarajan SriramKasinathan Madhu
Sep 1, 2005·European Journal of Medicinal Chemistry·Dharmarajan SriramGayatri Gopal
Oct 6, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Richard Frothingham
Dec 20, 2005·Pulmonary Pharmacology & Therapeutics·Maria Gabriella Matera
Dec 27, 2005·Antimicrobial Agents and Chemotherapy·Ed T BuurmanKathy MacCormack
Jan 6, 2006·Journal of Medicinal Chemistry·Jason A WilesBarton J Bradbury
Jan 18, 2006·Bioorganic & Medicinal Chemistry·Dharmarajan SriramRuth Vandana Devakaram
Feb 9, 2006·Bioorganic & Medicinal Chemistry Letters·Dharmarajan SriramSushma Pobba Reddy
Feb 14, 2006·Organic Letters·Judith F BlomKarl Gademann
Feb 17, 2006·Journal of Medicinal Chemistry·Chengxin ZhiRichard Storer
Mar 24, 2006·Bioorganic & Medicinal Chemistry Letters·Dharmarajan SriramL M Fisher
May 26, 2006·Antimicrobial Agents and Chemotherapy·Hee-Soo ParkJin-Hwan Kwak
Aug 4, 2006·Journal of Medicinal Chemistry·Mira M HinmanBruce A Beutel
Sep 2, 2006·Bioorganic & Medicinal Chemistry Letters·Gaiying ZhaoUte Möllmann
Nov 1, 2006·Antimicrobial Agents and Chemotherapy·Michelle M ButlerTerry L Bowlin
Nov 25, 2006·Bioorganic & Medicinal Chemistry Letters·Freddy RivaultGaëtan L A Mislin
Feb 17, 2007·Bioorganic & Medicinal Chemistry Letters·Sean T MurphyFreddy Rivault
Feb 20, 2007·Bioorganic & Medicinal Chemistry·Ales ImramovskýJarmila Kaustová
Mar 23, 2007·Bioorganic & Medicinal Chemistry Letters·Dharmarajan SriramDebjani Banerjee
Jun 23, 2007·Current Medicinal Chemistry·John B BremnerSiritron Samosorn
Aug 2, 2007·Accounts of Chemical Research·Bernard Meunier
Aug 29, 2007·Antimicrobial Agents and Chemotherapy·Karl DrlicaXilin Zhao
Sep 7, 2007·Bioorganic & Medicinal Chemistry Letters·Mauro V de AlmeidaMaria C S Lourenço
Oct 17, 2007·Antimicrobial Agents and Chemotherapy·Kazuki HoshinoTsuyoshi Otani

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Citations

Dec 10, 2013·Chemical Reviews·Claudine Mayer, Yves L Janin
Mar 30, 2011·Journal of Medicinal Chemistry·Jason A WilesMilind Deshpande
Sep 21, 2012·SAR and QSAR in Environmental Research·X H SunC X Wang
Feb 9, 2011·Nucleic Acids Research·Steven L PittsNeil Osheroff
Mar 23, 2012·Expert Opinion on Drug Metabolism & Toxicology·Aditi MulgaonkarDouglas H Sweet
Jul 30, 2011·Biochemical Pharmacology·Karen Bush, Michael J Pucci
Mar 5, 2015·Journal of Medicinal Chemistry·Gregory S Bisacchi
Aug 15, 2012·Chemical Biology & Drug Design·Oriana TabarriniVioletta Cecchetti
Apr 1, 2011·Expert Opinion on Therapeutic Patents·Hossein HeliKhashayar Karimian
Mar 31, 2015·Organic Letters·Dahye Kang, Sungwoo Hong
Oct 5, 2013·Clinical Microbiology Reviews·Michael J Pucci, Karen Bush
Feb 9, 2019·Journal of Molecular Modeling·Lidiane J MicheliniHamilton B Napolitano
Nov 14, 2019·ChemMedChem·Benedetta FoisDanijel Kikelj
Feb 8, 2019·Infectious Disorders Drug Targets·Azam MolapourPooya Rashvand
Aug 16, 2019·Clinical Microbiology Reviews·Joaquim Ruiz
Jan 12, 2017·The Journal of Antimicrobial Chemotherapy·Erika van EijkWiep Klaas Smits
Oct 21, 2016·Chemistry, an Asian Journal·Haojie MaGuosheng Huang
Dec 17, 2018·Journal of Controlled Release : Official Journal of the Controlled Release Society·Karolina MulasMarcin Sobczak
Apr 19, 2013·Organic Letters·Hikaru AbeMasakatsu Shibasaki

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