New radical methods for the potential synthesis of carbon-13 and carbon-14 labeled complex products

Journal of Labelled Compounds & Radiopharmaceuticals
Brad D Maxwell

Abstract

The isotopic labeling of molecules for agrichemical and pharmaceutical uses is becoming more challenging as molecules become larger, involve more stereochemistry, and as intellectual property rights become more complex. As such, isotope chemists need to continually add new isotopic methods to their armamentarium to successfully label complex molecules with carbon-13 and carbon-14. Recently, there has been a surge in the use of radicals to form new carbon-carbon bonds and for the incorporation of functional groups which can be used to incorporate isotopically labeled carbons. This review will describe some potential new radical methods for incorporating isotopically labeled carbon into complex molecules or into substrates that can be attached to late stage intermediates to generate labeled products.

References

Jan 1, 1972·Journal of Medicinal Chemistry·D A CovielloB Greenberg
May 8, 2007·Angewandte Chemie·Boris Gaspar, Erick M Carreira
May 14, 2008·Current Pharmaceutical Design·K C FylaktakidouD N Nicolaides
Sep 1, 2009·Journal of the American Chemical Society·Boris Gaspar, Erick M Carreira
Jan 17, 2014·Journal of the American Chemical Society·Julian C LoPhil S Baran
Jan 24, 2015·Journal of Labelled Compounds & Radiopharmaceuticals·Nelo R RiveraDavid Hesk
Jun 20, 2015·Journal of the American Chemical Society·Hai T DaoPhil S Baran
Jul 7, 2016·Angewandte Chemie·Jie WangPhil S Baran
Aug 23, 2016·Journal of the American Chemical Society·Fumihiko ToriyamaPhil S Baran
Jan 18, 2017·Journal of the American Chemical Society·Julian C LoPhil S Baran
Feb 12, 2017·Angewandte Chemie·Frederik SandfortPhil S Baran
Apr 15, 2017·Science·Chao LiPhil S Baran
Apr 21, 2017·Nature·Jacob T EdwardsPhil S Baran
Jun 22, 2017·Angewandte Chemie·Joel M SmithPhil S Baran

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of the American Pharmaceutical Association
H C REITZJ E CHRISTIAN
Chemical Society Reviews
Kevin J RomeroCorey R J Stephenson
Acta chirurgica Belgica
M de Roo
© 2022 Meta ULC. All rights reserved