New regulatory factors for melanogenesis: developmental changes in neonatal mice of various genotypes

Developmental Biology
M MurrayM L Lamoreux

Abstract

The biosynthesis of melanin occurs through sequential steps known as the Mason-Raper pathway. The initial steps are the conversion of tyrosine to dihydroxyphenylalanine (dopa) and of dopa to dopaquinone by the enzyme tyrosinase (EC 1.10.3.1). Until recently it was assumed that once these first two conversions were completed, the subsequent reactions occurred spontaneously. However, studies with mouse melanoma cells in culture revealed that subsequent steps in the pathway are also regulated. In this report, we demonstrate that these steps are also regulated in skins of fetal and newborn mice. The specific activities of the regulatory factors change during the first week after birth and differ in mice of different genotypes. The findings provide new insights into genetic and developmental regulation of the pigmentary system in mammals.

References

Jun 15, 1979·International Journal of Cancer. Journal International Du Cancer·T TaoM M Burger

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Citations

Jun 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·I J Jackson
Mar 1, 1991·Pigment Cell Research·J M Pawelek
Feb 14, 1990·Biochemical and Biophysical Research Communications·J M Pawelek
Jul 1, 1987·The Journal of Experimental Zoology·M L Lamoreux, P Pendergast
Aug 1, 1984·The Journal of Investigative Dermatology·J I BarberR A King
Nov 1, 1989·The Journal of Investigative Dermatology·A K ChakrabortyM Ichihashi

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