New ring C-seco limonoids from Brazilian Melia azedarach and their cytotoxic activity

Journal of Natural Products
Honglei ZhouYoshiyasu Fukuyama

Abstract

A methanol extract of the ripe fruits of Melia azedarach collected in Curitiba, Parana, Brazil, afforded seven new ring C-seco limonoids (1-7) together with three known limonoids (8-10). The structures of the new compounds were elucidated by NMR and MS analysis and comparison of spectral data with those of previously known compounds. Compounds 4 and 5 exhibited significant inhibitory activity against HeLa S3 cancer cells, whereas 1, 2, 3, and 8 showed weak cytotoxicity.

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Citations

Sep 8, 2011·Chemical Reviews·Qin-Gang Tan, Xiao-Dong Luo
Mar 29, 2007·Natural Product Reports·Joseph D Connolly, Robert A Hill
Jul 5, 2006·Biological & Pharmaceutical Bulletin·Shinya SuzukiMasao Sato
Feb 8, 2006·Biological & Pharmaceutical Bulletin·Amit Roy, Shailendra Saraf
Oct 6, 2005·Chemical & Pharmaceutical Bulletin·Honglei ZhouYoshiyasu Fukuyama
Aug 31, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nikoletta G NtalliPierluigi Caboni
Apr 17, 2010·Chemistry & Biodiversity·Lei ZhaoQing-Wen Shi
Dec 1, 2009·Journal of Natural Products·Ming-Hua YangLing-Yi Kong
Jul 10, 2010·Journal of Natural Products·Shi-Hui DongJian-Min Yue
Oct 12, 2010·Journal of Agricultural and Food Chemistry·Nikoletta G NtalliPierluigi Caboni
Dec 1, 2020·Journal of Natural Products·Min SongQing-Wen Zhang

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