New roles for model genetic organisms in understanding and treating human disease: report from the 2006 Genetics Society of America meeting.

Genetics
Allan SpradlingRobert Waterston

Abstract

Fundamental biological knowledge and the technology to acquire it have been immeasurably advanced by past efforts to understand and manipulate the genomes of model organisms. Has the utility of bacteria, yeast, worms, flies, mice, plants, and other models now peaked and are humans poised to become the model organism of the future? The Genetics Society of America recently convened its 2006 meeting entitled "Genetic Analysis: Model Organisms to Human Biology" to examine the future role of genetic research. (Because of time limitations, the meeting was unable to cover the substantial contributions and future potential of research on model prokaryotic organisms.) In fact, the potential of model-organism-based studies has grown substantially in recent years. The genomics revolution has revealed an underlying unity between the cells and tissues of eukaryotic organisms from yeast to humans. No uniquely human biological mechanisms have yet come to light. This common evolutionary heritage makes it possible to use genetically tractable organisms to model important aspects of human medical disorders such as cancer, birth defects, neurological dysfunction, reproductive failure, malnutrition, and aging in systems amenable to rapid and power...Continue Reading

Citations

Sep 6, 2008·Microbiology and Molecular Biology Reviews : MMBR·Elke Nevoigt
Oct 16, 2014·Genetics·Philip Hieter, Kym M Boycott
Jan 28, 2015·Genetics·Michael F WanglerHugo J Bellen
Sep 22, 2006·Genetics·Allan C Spradling
Feb 14, 2012·Studies in History and Philosophy of Biological and Biomedical Sciences·Sabina Leonelli, Rachel A Ankeny
Aug 2, 2012·Cancer Chemotherapy and Pharmacology·Renata MatuoJoão Antonio Pêgas Henriques

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