New routes to old places: PIK3R1 and PIK3R2 join PIK3CA and PTEN as endometrial cancer genes.

Cancer Discovery
Sandra Herrero-Gonzalez, Antonio Di Cristofano

Abstract

Cheung and colleagues identify PIK3R1 and PIK3R2, the genes encoding the α and β isoforms of the phosphatidylinositol 3-kinase (PI3K) p85 regulatory subunit, as additional mutation targets in endometrial cancer, and describe a novel mechanism leading to PTEN loss.

References

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Citations

Apr 18, 2013·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Ghayda M MirzaaWilliam B Dobyns
Oct 9, 2021·Genome Biology·Hussein MohsenMark B Gerstein

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