New self-assembled nanogels based on host-guest interactions: characterization and drug loading

Journal of Controlled Release : Official Journal of the Controlled Release Society
Ruxandra GrefPatrick Couvreur

Abstract

We show here, for the first time, that two neutral polymers may completely associate together in water to spontaneously form supramolecular nanoassemblies (nanogels) of spherical shape. The cohesion of these stable structures of about 200 nm is based upon a "lock and key" mechanism: inclusion complexes are formed between the hydrophobic alkyl chains grafted on a polysaccharide (dextran) and the molecular cavities contained in a poly-cyclodextrin polymer. Production yields reached 95%. It was established that all the alkyl chains were included within the cyclodextrins' cavities in these nanoassemblies. The multivalent character of the interactions between the two polymers ensures the stability of the nanoassemblies. Moreover, empty cyclodextrin units remained accessible for the inclusion of compounds of interest such as benzophenon or tamoxifen.

References

Sep 22, 1994·Nature·H Ringsdorf, J Simon
Mar 18, 1994·Science·R GrefR Langer
Apr 3, 2001·International Journal of Pharmaceutics·I BriggerP Couvreur
Jul 7, 2001·Science·R Langer
Jul 27, 2001·Nature·P G de Gennes
Jul 18, 2002·Nature Reviews. Drug Discovery·David A LaVanRobert Langer
Mar 5, 2003·International Journal of Pharmaceutics·Sylvia A Wissing, Rainer H Müller
Apr 15, 2004·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Maria José Alonso
Nov 2, 2004·European Journal of Immunology·Yvonne de KozakPatrick Couvreur

❮ Previous
Next ❯

Citations

Dec 25, 2008·Pharmaceutical Research·Christine Vauthier, Kawthar Bouchemal
May 31, 2008·Nanomedicine·Federica ChielliniEmo Chiellini
May 16, 2013·Advanced Drug Delivery Reviews·Jianxiang Zhang, Peter X Ma
Sep 26, 2014·Nanomedicine·Stephanie Deshayes, Ruxandra Gref
Apr 29, 2014·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Susana M N SimõesCarmen Alvarez-Lorenzo
Feb 8, 2016·Colloids and Surfaces. B, Biointerfaces·Claudia ConteFabiana Quaglia
May 31, 2011·Expert Opinion on Drug Delivery·Yiqing TangAndrew L Lewis
May 26, 2010·Journal of Drug Targeting·A L Laza-KnoerrP Couvreur
Jul 24, 2014·Artificial Cells, Nanomedicine, and Biotechnology·Ankita SharmaTanmay Markandeywar
Nov 20, 2015·Small·Carmen Stoffelen, Jurriaan Huskens
Dec 29, 2009·International Journal of Pharmaceutics·Xia Yang, Jin-Chul Kim
Jun 24, 2009·Colloids and Surfaces. B, Biointerfaces·A L NielsenK L Larsen
Apr 6, 2007·International Journal of Pharmaceutics·A BochotE Fattal
Nov 29, 2007·Journal of Biomedical Materials Research. Part a·S Daoud-MahammedR Gref
Oct 31, 2012·Chemistry : a European Journal·Erhan DenizSalvatore Sortino
Jul 6, 2011·Macromolecular Bioscience·Véronique WintgensCatherine Amiel
Nov 23, 2006·International Journal of Pharmaceutics·S Daoud-MahammedR Gref
Mar 6, 2012·International Journal of Pharmaceutics·Maria D Moya-OrtegaThorsteinn Loftsson
Feb 11, 2014·Carbohydrate Polymers·Eneko Larrañeta, José Ramón Isasi
Aug 28, 2012·Micron : the International Research and Review Journal for Microscopy·Victoria KlangNadejda B Matsko
Feb 14, 2015·Chemical Communications : Chem Comm·Susana M N SimõesCarmen Alvarez-Lorenzo
Aug 6, 2013·Carbohydrate Polymers·Zoltán FülöpThorsteinn Loftsson
Jan 27, 2015·Chemical Society Reviews·Xuejiao ZhangRainer Haag
Jun 28, 2016·Journal of Pharmaceutical Sciences·Iurii Antoniuk, Catherine Amiel
Apr 30, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Nobuyuki MorimotoKazunari Akiyoshi
Jan 13, 2012·Biomacromolecules·Véronique WintgensCatherine Amiel
May 12, 2012·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Resmi AnandSandra Monti
Aug 1, 2013·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Resmi AnandSandra Monti
Oct 27, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jinpeng WangZhengyu Jin
Jul 10, 2014·Chemical Communications : Chem Comm·Jianxun DingXuesi Chen
Jul 28, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Noufal KandothSalvatore Sortino
Sep 14, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Hongxia WangFuyuan Ding
Oct 13, 2017·Basic & Clinical Pharmacology & Toxicology·Chutimon Muankaew, Thorsteinn Loftsson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.