New Sesquiterpenes from Litsea verticillata

Journal of Natural Products
Hong-Jie ZhangHarry H S Fong

Abstract

Seven new sesquiterpenes, named litseagermacrane (1), 7-epi-eudesm-4(15)-ene-1alpha,6alpha-diol (2), 5-epi-eudesm-4(15)-ene-1beta,6beta-diol (4), litseahumulanes A (6) and B (7), and litseachromolaevanes A (11) and B (12), as well as the known compounds 7-epi-eudesm-4(15)-ene-1beta,6beta-diol (3), eudesm-4(15)-ene-1beta,6alpha-diol (5), octahydro-4-hydroxy-3alpha-methyl-7-methylene-alpha-(1-methylethyl)-1H-indene-1-methanol (8), 10-hydroxyl-15-oxo-alpha-cadinol (9), and aphanamol II (10), were isolated from an anti-HIV fraction of the leaves and twigs of Litsea verticillata Hance (Figure 1). Isolates 1, 4, and 12 were found to inhibit HIV-1 replication in a green fluorescent protein (GFP)-based reporter cell line (HOG.R5) with IC(50) values of 6.5 (27.5), 17.4 (73.1), and 28.0 (119.7) microg/mL (microM), respectively. The structures of these isolates were determined by spectral data including 1D and 2D NMR spectra. Compound 11 was confirmed by X-ray crystallographic analysis.

References


❮ Previous
Next ❯

Citations

Mar 20, 2010·Journal of Chemical Ecology·Francisco A MacíasJose M G Molinillo
Dec 1, 2011·Journal of Natural Medicines·Masataka MoriyasuPatrick B ChaloMutiso
Dec 14, 2011·Journal of Natural Products·Su-Ling WongIh-Sheng Chen
Mar 9, 2010·Bioscience, Biotechnology, and Biochemistry·Yun-Song WangJing-Hua Yang
Dec 5, 2012·International Journal of Molecular Sciences·Yun-Ting HuangIh-Sheng Chen
May 23, 2015·Marine Drugs·Chin-Soon PhanCharles Santhanaraju Vairappan
Jan 27, 2016·Journal of Ethnopharmacology·Yun-Song WangJing-Hua Yang
Dec 17, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yi ZhangTao Wang
Jan 12, 2016·Journal of Asian Natural Products Research·Xin-Hui TianYun-Heng Shen
Apr 16, 2016·The American Journal of Chinese Medicine·Yifu GuanHongjie Zhang
Aug 7, 2012·Chemical & Pharmaceutical Bulletin·Piseth KhievYoung-Won Chin
Jun 22, 2016·Journal of Asian Natural Products Research·Dang Thach TranCuong Pham Van
Nov 4, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hong-Jie ZhangDjaja Doel Soejarto
Jun 8, 2017·Journal of Natural Products·Jie Gao, Haji A Aisa
Dec 1, 2005·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Jian-Hua WangYong-Tang Zheng
Sep 15, 2005·Phytotherapy Research : PTR·Kaleab AsresSimon Gibbons
May 11, 2019·Natural Products and Bioprospecting·Rong TangYue-Hu Wang
Oct 16, 2012·Chemical Communications : Chem Comm·Gowrisankar ParthasarathyE Peter Kündig
Jun 15, 2013·Organic & Biomolecular Chemistry·Cang-Song LiaoYang Ye
Feb 22, 2011·Chemistry & Biodiversity·Nisha AgrawalMahabeer Prasad Dobhal
Mar 16, 2013·Chemistry & Biodiversity·Nisha AgrawalMahabeer P Dobhal
Jan 24, 2017·Phytochemistry·Hong-Jie ZhangLijun Rong
Dec 15, 2007·Journal of Natural Products·Hua-Dong ChenJian-Min Yue
Jul 27, 2021·Journal of Asian Natural Products Research·You WuXue-Ming Zhou
Nov 16, 2017·Journal of Agricultural and Food Chemistry·Feifei LiuLiya Li
Jun 20, 2020·Journal of Natural Products·Ling Ding, Christian Hertweck
Dec 6, 2019·Journal of Natural Products·Guo-Kai WangKuo-Hsiung Lee
Sep 30, 2021·Natural Product Research·Ling ChenWeifeng Dai

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.