New simple prognostic score for primary biliary cirrhosis: Albumin-bilirubin score

Journal of Gastroenterology and Hepatology
Anthony W H ChanKa-Fai To

Abstract

Serum albumin and bilirubin are the most significant independent prognostic factors to predict hepatic events in patients with primary biliary cirrhosis (PBC). We aimed to investigate the prognostic significance of a new prognostic score, the albumin-bilirubin (ALBI) score, among PBC patients. In a retrospective longitudinal cohort of 61 Chinese PBC patients with follow-up period up to 18.3 years, the prognostic performance of the ALBI in prediction of hepatic events was compared with other well-established prognostic scores: Child-Pugh score, model of end-stage liver disease, Mayo risk score, Yale, European, and Newcastle models. Fifteen patients (24.6%) developed hepatic events during follow-up. The c-index (0.894) and χ(2) by likelihood ratio test (36.34) of the ALBI score were highest in comparison to other models. The ALBI score was the only independent prognostic factor by multivariate analysis and its adjusted hazard ratio of developing hepatic event was 27.8 (P < 0.001). There were three prognostically different groups stratified by the ALBI score: ALBI grade 1 (≤ -2.60), grade 2 (> -2.60 to -1.39), and grade 3 (> -1.39) groups. The 2-, 5-, and 10-year event-free survivals for grade 1, grade 2, and grade 3 groups were 1...Continue Reading

References

Jul 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E R DicksonA Langworthy
Feb 15, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P S KamathW R Kim
Aug 30, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S UenoT Aikou
Mar 22, 2005·Journal of Hepatology·François Durand, Dominique Valla
Sep 27, 2005·The American Journal of Gastroenterology·Grace Lai-Hung WongHenry Lik-Yuen Chan
Mar 19, 2008·Liver International : Official Journal of the International Association for the Study of the Liver·Chien-Wei SuJaw-Ching Wu
Jun 9, 2009·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver
Jun 26, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Keith D LindorUNKNOWN American Association for Study of Liver Diseases
Jul 16, 2009·Seminars in Immunopathology·Simon HohenesterUlrich Beuers
Jul 17, 2010·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver
Feb 15, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Li-Na ZhangFeng-Chun Zhang
Dec 17, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Philip J JohnsonHidenori Toyoda

❮ Previous
Next ❯

Citations

Jan 12, 2016·Journal of Gastroenterology and Hepatology·Anthony W H ChanStephen L Chan
Aug 9, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Stephen L ChanWinnie Yeo
Sep 14, 2016·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Nikolaos AndreatosTimothy M Pawlik
Nov 5, 2016·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Mu-Xing LiJian-Qiang Cai
Oct 30, 2016·Journal of Gastroenterology and Hepatology·Anthony W H ChanStephen L Chan
Jun 4, 2016·Journal of Gastroenterology and Hepatology·Anthony W H ChanStephen L Chan
Jul 8, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Heng ZouKui-Jie Liu
Feb 21, 2018·European Journal of Gastroenterology & Hepatology·Yingyu ZhangJunqi Niu
Oct 26, 2018·The British Journal of Radiology·Daisuke YoshimaruTakayoshi Nishino
Mar 2, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Jonggi ChoiKang Mo Kim
Sep 16, 2017·Hepatology International·Sha ChenJidong Jia
Oct 26, 2018·World Journal of Gastroenterology : WJG·Ya-Fei ZhangYi-Ming Li
May 29, 2020·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Yasuo TakatsuTosiaki Miyati
Aug 13, 2017·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·R Diaz-BeveridgeJ Aparicio
Aug 23, 2019·Journal of Clinical Medicine·Koji FujitaTsutomu Masaki
Sep 6, 2020·Journal of the Chinese Medical Association : JCMA·Pei-Shan WuKuei-Chuan Lee
Jan 25, 2021·Annals of Surgical Oncology·Taisuke ImamuraKatsuhiko Uesaka
Jan 20, 2020·Journal of the American College of Surgeons·Alexander M FagensonKwan N Lau
Mar 1, 2021·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·Ruby Siu-Ting LauCharing Ching-Ning Chong
Mar 5, 2021·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Hyun Joon ParkHyung Hwan Moon
May 20, 2021·Journal of Clinical and Translational Hepatology·Yanyun ShuFan Du
Sep 8, 2021·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Hayato YamanaHiroshi Yatsuhashi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved