Jul 14, 2001

New sources and antifungal activity of sesquiterpene lactones

Fitoterapia
A F BarreroM Akssira

Abstract

In the search for new sources of sesquiterpene lactones, six Centaurea species have been analyzed. The activity against the fungus Cunninghamella echinulata of (+)-cnicin (1) and (+)-salonitenolide (2), isolated from the Centaurea plants, as well as that of (+)-costunolide (3), (-)-dehydrocostuslactone (4), (-)-lychnopholide (5) and (-)-eremantholide C (6), has been evaluated. Compounds 3 and 4 showed noticeable EC50 values, whilst more polar lactones were inactive. These results suggest that a relatively low polarity is one of the molecular requirements for the antifungal activity of sesquiterpene lactones.

  • References2
  • Citations32

Citations

Mentioned in this Paper

Costunolide
Cunninghamella
Cnicin
Antibiotics, Antifungal
Sphaeranthus
Cunninghamella echinulata
Dehydrocostuslactone
Sesquiterpenes
Lactones
Fungi

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