New steps forward in the neuroactive steroid field

The Journal of Steroid Biochemistry and Molecular Biology
Silvia GiattiRoberto Cosimo Melcangi

Abstract

Evidence accumulated in recent years suggests that the systemic treatment with neuroactive steroids, or the pharmacological modulation of its production by brain cells, represent therapeutic options to promote neuroprotection. However, new findings, which are reviewed in this paper, suggest that the factors to be considered for the design of possible therapies based on neuroactive steroids are more complex than previously thought. Thus, although as recently reported, the nervous system regulates neuroactive steroid synthesis and metabolism in adaptation to modifications in peripheral steroidogenesis, the neuroactive steroid levels in the brain do not fully reflect its levels in plasma. Even, in some cases, neuroactive steroid level modifications occurring in the nervous tissues, under physiological and pathological conditions, are in the opposite direction than in the periphery. This suggests that the systemic treatment with these molecules may have unexpected outcomes on neural steroid levels. In addition, the multiple metabolic pathways and signaling mechanisms of neuroactive steroids, which may change from one brain region to another, together with the existence of regional and sex differences in its neural levels are additi...Continue Reading

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Citations

Apr 27, 2016·Neuroscience and Biobehavioral Reviews·GianCarlo Panzica, Roberto C Melcangi
Jun 25, 2016·Journal of Molecular Endocrinology·Silvia GiattiMarzia Pesaresi
Jan 20, 2017·Journal of Perinatology : Official Journal of the California Perinatal Association·K R McCallieV K Bhutani
May 19, 2019·Journal of Neuroendocrinology·Silvia GiattiRoberto Cosimo Melcangi
Apr 21, 2018·Endocrine·Silvia GiattiRoberto Cosimo Melcangi
Apr 26, 2018·Molecular Medicine Reports·Shu-Jie ZhaoGuo-Yong Yin
Aug 28, 2020·Frontiers in Neuroscience·Alessandra ColciagoValerio Magnaghi
Jan 30, 2018·Frontiers in Aging Neuroscience·Esperanza Navarro-PardoAntonio Cano
Aug 16, 2018·Cellular and Molecular Neurobiology·Silvia GiattiRoberto Cosimo Melcangi
Dec 2, 2020·International Journal of Molecular Sciences·Eva FalvoSilvia Giatti
Dec 29, 2020·Neuroscience and Biobehavioral Reviews·Regine Sitruk-WareCesar V Borlongan
Aug 4, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zhi-Kun QiuJi-Sheng Chen
Jul 26, 2017·Frontiers in Neuroendocrinology·S GiattiR C Melcangi

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