New steroidal glycosides from the fibrous roots of Ophiopogon japonicus

Journal of Asian Natural Products Research
Chang-Ling DuanXu-Dong Tang

Abstract

Two new steroidal glycosides (named fibrophiopogonins A, B), along with one known glycoside, were isolated from the fibrous roots of Ophiopogon japonicus (Liliaceae). Comprehensive spectroscopic analysis, including 2D NMR spectroscopy, and the results of acid hydrolysis allowed the chemical structure of the compounds to be assigned as 26-[(O-β-D-glucopyranosyl-(1 → 6)-D-glucopyranosyl)]-barogenin- 3-O-[α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside and (25R)-26-[(O- β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl)]- 3β,22α,26- trihydroxyfurost- 5-ene-3-O-[α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside. This is the first isolation of a cholestane glycoside with disaccharide moiety from a Ophiopogon species. The cytotoxic activities of 1~3 against A375 and MCF-7 cells are described.

References

Oct 4, 2006·Chemical & Pharmaceutical Bulletin·Kun ZouGuangzhong Tu
Sep 15, 2010·Journal of Asian Natural Products Research·Chang-Ling DuanPeng-Fei Tu
Jun 15, 2011·Bioscience, Biotechnology, and Biochemistry·Yuan QuJianhua Qi
Nov 6, 2012·Steroids·Ning LiPeng-Fei Tu
Apr 23, 2013·Journal of Asian Natural Products Research·Yu GuoBai-Ping Ma
Dec 18, 2013·Journal of Asian Natural Products Research·Zhi-Yun KangDe-Quan Yu

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Methods Mentioned

BETA
column chromatography
NMR

Software Mentioned

GraphPad Prism

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