New strategies for advanced neuroendocrine tumors in the era of targeted therapy

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Mei DongJames C Yao

Abstract

Low- to intermediate-grade neuroendocrine tumor (NET) constitutes a group of indolent malignancies that share the capacity for secreting hormones and neuroamines. Until recently, there were few therapeutic options for oncologic control. The PROMID study showed that octreotide long-acting repeatable formulation can delay tumor growth in midgut NETs. And, recent phase III studies showed both everolimus and sunitinib improved progression-free survival in pancreatic NETs, validating the phosphoinositide 3-kinase/Akt/mTOR pathway and angiogenesis as important targets for further advances. Ongoing and planned pivotal studies targeting these pathways in other NET subtypes may widen their therapeutic application. Development of rational combinations may further improve therapeutic outcome. These successes and our improved understanding of the underlying molecular biology are likely to lead to further important advances on the horizon.

Associated Clinical Trials

References

Sep 1, 1992·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E T JansonK Oberg
Mar 14, 2000·Journal of Magnetic Resonance Imaging : JMRI·R C SemelkaJ T Woosley
Feb 6, 2003·Cancer·Irvin M ModlinMark Kidd
Feb 2, 1963·Lancet·E D WILLIAMS, M SANDLER
Dec 24, 2003·Acta Oncologica·Isac I SchnirerJaffer A Ajani
Apr 14, 2004·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·F Gibril, R T Jensen
Dec 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Maria A KouvarakiJames C Yao
May 28, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Gordon G WangAsif Rashid
Sep 27, 2005·Best Practice & Research. Clinical Gastroenterology·Dermot O'Toole, Philippe Ruszniewski
Sep 27, 2005·Best Practice & Research. Clinical Gastroenterology·Tahir Shah, Martyn Caplin
Jan 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Matthew H KulkeCharles S Fuchs
Jul 14, 2006·Advances in Experimental Medicine and Biology·Florencia G QueDavid M Nagorney
Aug 22, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kutluk OktayLinda Vahdat
Mar 27, 2007·Best Practice & Research. Clinical Endocrinology & Metabolism·Andrea G Rockall, Rodney H Reznek
Mar 27, 2007·Best Practice & Research. Clinical Endocrinology & Metabolism·Anders SundinHåkan Orlefors
Mar 27, 2007·Best Practice & Research. Clinical Endocrinology & Metabolism·James C Yao
Sep 27, 2007·Annals of Surgical Oncology·James C YaoDouglas B Evans
Dec 11, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Cristina R FerronePeter J Allen
Mar 8, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James C YaoJaffer A Ajani
May 21, 2008·International Journal of Cancer. Journal International Du Cancer·Manal M HassanJames C Yao
Jun 21, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James C YaoDouglas B Evans
Jul 8, 2008·Endocrine-related Cancer·Ulrich-Frank PapeBertram Wiedenmann
Jul 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Matthew H KulkeCharles S Fuchs
Aug 14, 2008·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·U KniggeF Stadil
Sep 23, 2008·World Journal of Gastroenterology : WJG·Sara MassironiDario Conte
Jan 2, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Matthew H KulkeMark S Redston
Jan 9, 2009·The New England Journal of Medicine·Matthew H KulkeJames C Yao
Nov 18, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Edoardo MissiagliaAldo Scarpa
Mar 18, 2010·British Journal of Cancer·N C TurnerT Meyer
Jan 26, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Matthew H KulkeJames C Yao
Feb 11, 2011·The New England Journal of Medicine·Eric RaymondPhilippe Ruszniewski
Feb 11, 2011·The New England Journal of Medicine·James C YaoUNKNOWN RAD001 in Advanced Neuroendocrine Tumors, Third Trial (RADIANT-3) Study Group
May 31, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Elizabeth AllenDouglas Hanahan
Aug 11, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·James C Yao, Alexandria Phan
Oct 14, 2011·The Journal of Clinical Endocrinology and Metabolism·James C YaoKjell E Öberg

❮ Previous
Next ❯

Citations

Sep 26, 2013·AJR. American Journal of Roentgenology·Kyung Won KimNikhil H Ramaiya
Oct 23, 2013·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Georgios C SotiropoulosGregory Kouraklis
Jul 18, 2015·Clinical Journal of Gastroenterology·Shiro KimbaraHironobu Minami
Jun 3, 2014·International Journal of Surgery·Aldo RoccaGermano Guerra
Mar 13, 2014·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Lorna R WoodbridgeKatie L Planche
Jul 18, 2015·Clinical Journal of Gastroenterology·Yoshihito KanoMamoru Watanabe
Aug 14, 2012·Journal of Gastroenterology·Tetsuhide ItoRobert T Jensen
Sep 24, 2015·International Journal of Oncology·Puja KhannaGyeong Hun Baeg
Feb 27, 2016·Future Oncology·Alberto ManganoGianlorenzo Dionigi
Sep 24, 2013·Orvosi hetilap·Miklós Tóth
May 27, 2014·Biochimica Et Biophysica Acta·Wei YangSamuel J Klempner
Jan 29, 2014·Oncogene·N AkenoK A Wikenheiser-Brokamp
Jan 19, 2017·International Journal of Molecular Sciences·Akihiro OhmotoShinichi Yachida
Dec 12, 2012·Current Opinion in Endocrinology, Diabetes, and Obesity·H Christian Weber
Aug 29, 2013·The Journal of Biological Chemistry·Jing HeWilliam C Wimley
Jun 18, 2017·AAPS PharmSciTech·Saad M AlshahraniFaiyaz Shakeel
Sep 1, 2015·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Chan ShenJames C Yao
May 3, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Sophie J van AsseltElisabeth G E de Vries

❮ Previous
Next ❯

Related Concepts

Related Feeds

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.