PMID: 16623265Apr 21, 2006Paper

New strategies in multiple organ dysfunction syndrome therapy for sepsis

Srpski arhiv za celokupno lekarstvo
Maja SurbatovićPredrag Romić

Abstract

Despite more than 20 years of extensive research, sepsis and/or trauma induced multiple organ dysfunction syndrome (MODS) remain the chief cause of death in intensive care units, with mortality rates between 30% and 80%. Early goal-directed therapy (EGDT), use of drotrecogin alfa (activated), tight control of hyperglycaemia, and adrenal replacement therapy (low doses of corticosteroids), all constitute new treatment strategies. In future, a combination of therapies should be individually adjusted for each patient.

References

Mar 10, 2001·The New England Journal of Medicine·G R BernardUNKNOWN Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group
Jul 11, 2001·Critical Care Medicine·D C Angus, R S Wax
Aug 4, 2001·The New England Journal of Medicine·B K NallamothuK A Eagle
Jan 17, 2002·The New England Journal of Medicine·E RiversUNKNOWN Early Goal-Directed Therapy Collaborative Group
Aug 21, 2002·JAMA : the Journal of the American Medical Association·Djillali AnnaneEric Bellissant
Apr 12, 2003·Current Opinion in Pulmonary Medicine·Sat Sharma, Anand Kumar
May 1, 2004·Critical Care Medicine·Patricia C Y Liaw

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Citations

Nov 8, 2013·TheScientificWorldJournal·Maja SurbatovicSonja Radakovic
Dec 29, 2013·Mediators of Inflammation·Maja SurbatovicSonja Radakovic

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