New Subsolid Pulmonary Nodules in Lung Cancer Screening: The NELSON Trial

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
Joan E WalterMatthijs Oudkerk

Abstract

Low-dose computed tomography (LDCT) lung cancer screening is recommended in the United States. While new solid nodules after baseline screening have a high lung cancer probability at small size and require lower size cutoff values than baseline nodules, there only is limited evidence on management of new subsolid nodules. Within the Dutch-Belgian randomized controlled LDCT lung cancer screening trial (NELSON), 7557 participants underwent baseline screening between April 2004 and December 2006. Participants with new subsolid nodules detected after the baseline screening round were included. In the three incidence screening rounds, 60 new subsolid nodules (43 [72%] part-solid, 17 [28%] nonsolid) not visible in retrospect were detected in 51 participants, representing 0.7% (51 of 7295) of participants with at least one incidence screening. Eventually, 6% (3 of 51) of participants with a new subsolid nodule were diagnosed with (pre-)malignancy in such a nodule. All (pre-)malignancies were adenocarcinoma (in situ) and diagnostic workup (referral 950, 364, and 366 days after first detection, respectively) showed favorable staging (stage I). Overall, 67% (33 of 49) of subsolid nodules with an additional follow-up screening were resolv...Continue Reading

Citations

Mar 7, 2020·Journal of Clinical Medicine·Yi-Han LinHan-Shui Hsu
Jul 18, 2020·Journal of the Chinese Medical Association : JCMA·Yi-Han Lin, Han-Shui Hsu
Sep 4, 2020·European Respiratory Review : an Official Journal of the European Respiratory Society·Sharad Chandrika, Lonny Yarmus
Oct 14, 2020·Nature Reviews. Clinical Oncology·Matthijs OudkerkJohn K Field
Aug 6, 2019·Mayo Clinic Proceedings·Narjust DumaJulian R Molina
Oct 9, 2020·Chest·Lea AzourWilliam H Moore
Dec 22, 2020·Journal of the American College of Surgeons·Robert M Van HarenSandra L Starnes
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Jul 3, 2021·Cancers·Anton SchreuderCornelia M Schaefer-Prokop
Jun 16, 2021·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Morten BorgOle Hilberg

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