New substituted 4-arylaminoquinazolines as potent inhibitors of breast tumor cell lines: in vitro and docking experiments

European Journal of Medicinal Chemistry
André N de OliveiraNelci F Hoehr

Abstract

The arylquinazolines represent significant advances in the clinical management of breast cancer. Nevertheless some confirmatory studies must be considered to foster the use of anti-EGFR therapies including safety and clinical use. Two 4-arylaminoquinazoline derivatives, recently synthesized, were tested as kinase inhibitors and their citotoxicities showed potent growth inhibitory activity in breast tumor cell lines (MCF-7). The predicted complex structure of quinazoline inhibitors with EGFR protein from molecular docking provided a stereoview of the binding site correlated with structure activity, affording important information about structure-based drug design.

Citations

Dec 7, 2013·European Journal of Medicinal Chemistry·Mohammad ArshadInho Choi
Oct 25, 2011·PLoS Computational Biology·Shun-Chieh YangCalvin Yu-Chian Chen
Dec 17, 2011·PloS One·Shun-Chieh YangCalvin Yu-Chian Chen
Mar 29, 2020·Frontiers in Microbiology·Richa SharmaPascal Piveteau
Aug 8, 2021·Bioorganic & Medicinal Chemistry Letters·Aiten M SolimanMostafa M Ghorab

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