New susceptibility locus for coronary artery disease on chromosome 3q22.3

Nature Genetics
Jeanette ErdmannHeribert Schunkert


We present a three-stage analysis of genome-wide SNP data in 1,222 German individuals with myocardial infarction and 1,298 controls, in silico replication in three additional genome-wide datasets of coronary artery disease (CAD) and subsequent replication in approximately 25,000 subjects. We identified one new CAD risk locus on 3q22.3 in MRAS (P = 7.44 x 10(-13); OR = 1.15, 95% CI = 1.11-1.19), and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43 (P = 4.81 x 10(-7); OR = 1.08, 95% CI = 1.05-1.11).


Jan 28, 2003·Circulation Journal : Official Journal of the Japanese Circulation Society·Yuichi SatoMotoichiro Takahashi
Mar 5, 2003·Circulation·UNKNOWN Atherosclerosis, Thrombosis, and Vascular Biology Italian Study Group
Apr 24, 2004·Science·Gilean A T McVeanPeter Donnelly
May 5, 2007·Science·Anna HelgadottirKari Stefansson
May 5, 2007·Science·Ruth McPhersonJonathan C Cohen
Jun 8, 2007·Nature·UNKNOWN Wellcome Trust Case Control Consortium
Jun 19, 2007·Nature Genetics·Jonathan MarchiniPeter Donnelly
Jun 29, 2007·Nature Genetics·Andrew G Clark, Jian Li
Jul 20, 2007·The New England Journal of Medicine·Nilesh J SamaniUNKNOWN WTCCC and the Cardiogenics Consortium
Aug 4, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Elena Galkina, Klaus Ley
Oct 19, 2007·Nature·UNKNOWN International HapMap ConsortiumJohn Stewart
Jan 26, 2008·Biometrical Journal. Biometrische Zeitschrift·Andreas ZieglerJohn R Thompson
Feb 27, 2008·Genetic Epidemiology·Frank Dudbridge, Arief Gusnanto
Apr 29, 2008·American Journal of Human Genetics·Alexander P ReinerRonald M Krauss
May 10, 2008·BMC Proceedings·Daniel F SchwarzInke R König
May 24, 2008·The New England Journal of Medicine·Sekar Kathiresan, UNKNOWN Myocardial Infarction Genetics Consortium
Jul 26, 2008·Nature Nanotechnology
Dec 9, 2008·Nature Genetics·Sekar KathiresanL Adrienne Cupples

❮ Previous
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Jun 11, 2009·Human Genetics·Kunihiko HinoharaAkinori Kimura
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Mar 4, 2011·Current Atherosclerosis Reports·S SivapalaratnamG M Dallinga-Thie
Apr 18, 2013·Current Atherosclerosis Reports·Egle IncalcaterraCalogero Caruso
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Jun 19, 2010·Journal of Cardiovascular Translational Research·Robert RobertsLi Chen
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Nov 26, 2010·Journal of Human Genetics·Asako AokiToshihiro Tanaka
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Jan 24, 2012·Nature Genetics·Maya GhoussainiDouglas F Easton
Dec 4, 2012·Nature Genetics·Panos DeloukasNilesh J Samani
Mar 8, 2011·Nature Genetics·UNKNOWN Coronary Artery Disease (C4D) Genetics Consortium
May 5, 2010·Nature Reviews. Cardiology·Iftikhar J Kullo, Leslie T Cooper
May 15, 2012·DNA and Cell Biology·Mercedes García-BermúdezMiguel A González-Gay
Jun 9, 2009·Cardiovascular Research·Karin R SipidoVirginija Dambrauskaite
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Nov 23, 2010·European Heart Journal·Jeanette ErdmannHeribert Schunkert
Jul 6, 2013·European Heart Journal·Vinicius TraganteUNKNOWN SMART study group
Aug 31, 2011·Human Molecular Genetics·John F Peden, Martin Farrall
Mar 22, 2012·International Journal of Epidemiology·Terence DwyerGerald S Berenson
Feb 3, 2011·Cardiology in Review·Edwin HoGemma A Figtree
Dec 21, 2011·Cardiology in Review·Emil M deGomaDaniel J Rader
Sep 6, 2013·Current Opinion in Lipidology·Lesca M Holdt, Daniel Teupser
Aug 14, 2012·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M G HeckmanO A Ross
Dec 2, 2010·Annals of Human Genetics·Teresa Ferreira, Jonathan Marchini
Sep 11, 2009·American Journal of Physiology. Cell Physiology·Alexander J Michels, Tory M Hagen
Jun 15, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Ani ManichaikulWeibin Shi
Dec 18, 2009·PPAR Research·Jean DallongevilleAline Meirhaeghe
Feb 18, 2011·Human Heredity·Christina LoleyInke R König
May 25, 2011·Circulation. Cardiovascular Genetics·Philipp S WildStefan Blankenberg
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