New synthesis and biological evaluation of benzothiazole derivates as antifungal agents

Journal of Agricultural and Food Chemistry
Natividad Herrera CanoAna N Santiago

Abstract

In search of new antifungal agrochemicals that could replace commercially available, aryl-2-mercaptobenzothiazoles were synthesized. They were prepared by two methodologies, using both photostimulated reaction and microwave assisted reaction. These reactions took place without the use of metallic catalyst by a one-pot procedure with excellent yields (70-98%). Synthesized compounds were evaluated for fungal growth inhibition against Botrytis cinerea. Most of the compounds have an excellent antifungal activity, and three of these showed a superior inhibitory effect to commercial fungicide Triadimefon. IC50 values observed for 2-(phenylthio)benzothiazole, 2-(2-chlorophenylthio)benzothiazole, and 2-(3-chlorophenyl thio)benzothiazole were 0.75, 0.69, and 0.65 μg mL(-1), respectively.

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Citations

Jun 27, 2020·Organic & Biomolecular Chemistry·You ZiIvan Vilotijevic
Sep 12, 2017·Frontiers in Microbiology·Aurélien Bailly, Laure Weisskopf
Nov 13, 2020·Molecular Diversity·Ayushi SethiyaShikha Agarwal
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Larisa V ZhilitskayaNina O Yarosh
Nov 4, 2017·Journal of Agricultural and Food Chemistry·María Sol BallariAna Noemí Santiago

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