New take on comparative immunology: relevance to immunotherapy.

Immunotherapy
Ena WangF M Marincola

Abstract

It is becoming increasingly recognized that experimental animal models, while useful to address monothematic biological questions, bear unpredictable relevance to human disease. Several reasons have been proposed. However, the uncontrollable nature of human genetics and the heterogeneity of disease that can only be replicated with difficulty experimentally play a leading role. Comparative immunology is a term that generally refers to the analysis of shared or diverging facets of immunology among species; these comparisons are carried out according to the principle that evolutionarily conserved themes outline biologic functions universally relevant for survival. We propose that a similar strategy could be applied to searching for themes shared by distinct immune pathologies within our own species. Identification of common patterns may outline pathways necessary for a particular determinism to occur, such as tissue-specific rejection or tolerance. This approach is founded on the unproven but sensible presumption that nature does not require an infinite plethora of redundant mechanisms to reach its purposes. Thus, immune pathologies must follow, at least in part, common means that determine their onset and maintenance. Commonaliti...Continue Reading

References

Aug 1, 1992·The Journal of Clinical Investigation·M C SnellerW Strober
Aug 3, 1994·Journal of the National Cancer Institute·S A RosenbergD E White
Apr 1, 1993·Trends in Genetics : TIG·B Vogelstein, K W Kinzler
Jan 17, 1996·Journal of the National Cancer Institute·N P RestifoS A Rosenberg
Dec 1, 1996·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·D A Rew
Feb 14, 1998·European Journal of Endocrinology·T DahlmanK Westermark
Feb 18, 1998·International Journal of Cancer. Journal International Du Cancer·J N CormierF M Marincola
May 30, 1998·JAMA : the Journal of the American Medical Association·R Peters, R Sikorski
Dec 10, 1998·Nature Medicine·A Cucuianu
Jan 1, 1999·Nature·C LengauerB Vogelstein
Mar 26, 1999·American Journal of Human Genetics·C E JacksonJ M Puck
Apr 3, 1999·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·D A Rew
Apr 14, 1999·Proceedings of the National Academy of Sciences of the United States of America·D A MartinM J Lenardo
Sep 24, 1999·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·N Ferrara
Dec 11, 1999·Immunity·R CallardJ Stark
Feb 17, 2000·Nature
May 24, 2000·Cellular and Molecular Life Sciences : CMLS·E OttavianiS Genedani
Aug 30, 2000·Nature·C M PerouD Botstein
Dec 15, 2000·Immunology Today·E Wang, F M Marincola
Jul 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·G A OhnmachtF M Marincola
Mar 7, 2002·Proceedings of the National Academy of Sciences of the United States of America·Patrizia FarciRobert H Purcell
Apr 27, 2002·Science·Jonathan Rees
May 30, 2002·Genome Génome / Conseil National De Recherches Canada·Daryl J Somers, Goewin Demmon
Jul 12, 2002·The Journal of Allergy and Clinical Immunology·Daniel RotrosenJeffrey A Bluestone
Oct 22, 2002·Proceedings of the National Academy of Sciences of the United States of America·Werner E MayerMax D Cooper
Dec 5, 2002·Current Molecular Medicine·Alessia Verani, Paolo Lusso
Dec 13, 2002·Proceedings of the National Academy of Sciences of the United States of America·Robert L StrausbergUNKNOWN Mammalian Gene Collection Program Team
Jan 17, 2003·The New England Journal of Medicine·Lin ZhangGeorge Coukos

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Citations

Jun 19, 2009·Journal of Translational Medicine·Hideaki TaharaFrancesco M Marincola
Feb 6, 2010·Journal of Translational Medicine·Robert B NussenblattAlan N Schechter
May 18, 2011·Journal of Internal Medicine·Francesco M Marincola

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xenografts
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