New techniques for augmenting saliva collection: bacon rules and lozenge drools

Clinical Therapeutics
Jeremy C PeresE A Shirtcliff

Abstract

Saliva is a reliable, noninvasive, and cost-effective alternative to biomarkers measured in other biological fluids. Within certain populations, saliva sampling may be difficult because of insufficient saliva flow, which may compromise disease diagnosis or research integrity. Methods to improve flow rates (eg, administering citric acid, chewing gum, or collecting cotton) may compromise biomarker integrity, especially if the methods involve the presence of a collection aid in the oral cavity. Anecdotal strategies (eg, looking at pictures of food or imagining food) have not been evaluated to date. In this study, we evaluate whether 2 novel collection techniques improve saliva flow or interfere with assay of common biomarkers (ie, cortisol, dehydroepiandrosterone, and testosterone). We evaluate an over-the-counter anhydrous crystalline maltose lozenge intended to increase saliva production for patients with xerostomia long after the lozenge dissolves. We then evaluate whether the smell of freshly cooked bacon stimulates a pavlovian-type reflex. Saliva was collected from 27 healthy young adults (aged 20-34 years; 12 men) on a basal day and a lozenge day, providing 5 samples at 15-minute intervals. Twenty participants then returned ...Continue Reading

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Citations

Jul 1, 2017·Frontiers in Public Health·Olga MiočevićElizabeth A Shirtcliff
Apr 11, 2020·Clinical Pharmacology : Advances and Applications·Rob TurnerTim Shea
Feb 7, 2021·The Clinical Respiratory Journal·Narelle S CoxAnne E Holland

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