New techniques for studying human muscle function, metabolism, and fatigue

Muscle & Nerve
R H Edwards

Abstract

To analyze human muscle function, metabolism, and fatigue in both health and disease a variety of techniques may be employed. The most fundamental approach is the measurement of force, which may be generated by either voluntary or electrically stimulated contractions. More detailed information concerning the mechanisms of both weakness and fatigue can be obtained when the electromyogram is recorded simultaneously with force. The needle biopsy technique is recommended for the histological and histochemical examination of skeletal muscle. It has the advantage of being rapid and repeatable and has proved suitable for both diagnostic and follow-up purposes. Recently developed techniques allow the study of mitochondrial function and protein synthesis. Topical nuclear magnetic resonance spectroscopy is a new and exciting technique for the noninvasive study of muscle metabolism. The opportunities offered by this technique are largely complementary to others available and unlikely to replace them as diagnostic and monitoring tools.

References

Mar 29, 1975·Lancet·R H EdwardsG J Batra
Sep 17, 1977·Lancet·C M Wiles, R H Edwards
Sep 1, 1977·The Journal of Physiology·P Andersen, J Henriksson
May 1, 1978·Clinical Science and Molecular Medicine·R H Edwards
Sep 1, 1977·Journal of Neurology, Neurosurgery, and Psychiatry·N J BrandtC Krarup
Nov 1, 1977·Rheumatology and Rehabilitation·A Young, R H Edwards
Nov 1, 1977·The Journal of Physiology·R H EdwardsP A Merton
Jun 1, 1978·Clinical Science and Molecular Medicine·B Bigland-RitchieR H Edwards
Mar 1, 1977·Clinical Science and Molecular Medicine·R H EdwardsD A Jones
Mar 1, 1977·Clinical Science and Molecular Medicine·R F MouldsR H Edwards
Apr 1, 1977·Clinical Science and Molecular Medicine·A J SargeantA Young
Oct 1, 1977·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·J D MacDougallJ R Sutton
Jan 1, 1972·Physiological Reviews·R I Close
Jan 1, 1972·Naunyn-Schmiedeberg's Archives of Pharmacology·K O Ellis, S H Bryant
Oct 1, 1971·Acta Physiologica Scandinavica·U Freyschuss, E Knutsson
Jan 1, 1972·The Journal of Physiology·J A Stephens, A Taylor
Nov 1, 1970·The American Journal of Physiology·J I Spande, B A Schottelius
Nov 1, 1966·The American Journal of Physiology·R A Murphy
Nov 1, 1983·Muscle & Nerve·R H EdwardsD A Jones
Oct 1, 1982·The American Journal of Clinical Nutrition·J LopesK N Jeejeebhoy
Jan 1, 1983·Clinical Science·D J NewhamR H Edwards
Jan 1, 1983·Journal of the Neurological Sciences·K R Mills, R H Edwards
May 28, 1981·The New England Journal of Medicine·B D RossJ Falconer-Smith
Nov 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·B ChanceA Sapega
May 1, 1980·British Medical Bulletin·R H Edwards
Jan 1, 1981·Annual Review of Biochemistry·D G Gadian, G K Radda
Mar 11, 1982·Nature·M J RennieD E Matthews
Nov 1, 1981·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·A Y Belanger, A J McComas
Mar 29, 1954·The Journal of Physiology·P A MERTON
May 3, 1965·Biochemical and Biophysical Research Communications·S TARUIM NISHIKAWA

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Citations

Jan 1, 1990·European Journal of Applied Physiology and Occupational Physiology·T ObergR Kadefors
Jan 1, 1985·Journal of Neurology·F Cornelio, S Di Donato
Jan 1, 1988·European Journal of Applied Physiology and Occupational Physiology·R H Edwards
Mar 1, 1993·World Journal of Surgery·T Christensen, H Kehlet
Feb 1, 1992·Electroencephalography and Clinical Neurophysiology·C BalestraK Hainaut
Sep 3, 1988·Lancet
Mar 1, 1991·Journal of Neurology, Neurosurgery, and Psychiatry·R J van der PloegH J Oosterhuis
Dec 1, 1989·Acta Odontologica Scandinavica·M G TzakisG E Carlsson
Aug 1, 1987·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·L V Christensen
Aug 1, 1989·Muscle & Nerve·K Hainaut, J Duchateau
Apr 1, 1986·Australian and New Zealand Journal of Medicine·F MechlerJ N Walton
Nov 4, 2017·Journal of Neural Engineering·Alie J BuckmireAndrew J Fuglevand
Apr 11, 2000·Journal of Speech, Language, and Hearing Research : JSLHR·D P Kuehn, J B Moon
Feb 10, 2006·Intensive Care Medicine·M EikermannJ Peters
Jun 20, 2001·Acta Physiologica Scandinavica·K S Sunnerhagen, G Grimby
Jan 1, 1986·Acta Medica Scandinavica. Supplementum·R H Edwards
Jun 1, 1992·The American Journal of Physiology·L V ThompsonR H Fitts
Oct 1, 2020·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·M John LuuDavid F Collins
Dec 1, 1991·Biochemical Medicine and Metabolic Biology·K A LuckinG A Klug

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