NEW technologies for meeting the global demand for pandemic influenza vaccines

Biologicals : Journal of the International Association of Biological Standardization
David S Fedson

Abstract

A new influenza pandemic is expected and if caused by the H5N1 virus it could be severe. Antiviral agents will be unavailable to most people and vaccines are regarded as the mainstay of protection. Development of inactivated H5N1 vaccines has been slow because of reluctance by US regulatory authorities to consider adjuvanted formulations and the unwillingness of Western European governments to fund vaccine trials. With effective political leadership, large amounts of live-attenuated and recombinant hemagglutinin pandemic vaccines could be produced quickly in existing facilities using egg-based technologies. New types of influenza vaccines, new technologies for their production and new adjuvants to make them more immunogenic are receiving the attention of scientists and vaccine developers. These technologies could help meet the global demand for pandemic vaccines, but only if they are coupled with improvements in the human infrastructure necessary for pandemic vaccination.

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Citations

Sep 5, 2012·Applied Microbiology and Biotechnology·Bo SunChunlai Jiang
Apr 28, 2012·BMC Biotechnology·Elizabeth MortimerEdward P Rybicki
Jul 28, 2010·PloS One·José M Aguilar-YáñezMario M Alvarez
Feb 26, 2009·Emerging Infectious Diseases·David S Fedson
Oct 23, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David S Fedson
Dec 19, 2015·Research in Veterinary Science·Tina LombardoMaura Ferrari
Jul 19, 2015·Vaccine·Françoise AubritKlaus Schwamborn
Jul 29, 2009·European Journal of Immunology·Flora CastellinoRino Rappuoli
Jun 12, 2013·Biotechnology Progress·Pamela B Sánchez-ArreolaMario M Alvarez
Jun 29, 2012·The Journal of General Virology·Zhi SunYing Fang
Sep 28, 2012·Journal of Laboratory Automation·Holger WirzAndre Sharon

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