New terminology for intrauterine endometrial samples: a group study by the Japanese Society of Clinical Cytology

Acta Cytologica
Kenji YanohYoshiaki Norimatsu

Abstract

To evaluate the sensitivity and specificity of endometrial cytology obtained by intrauterine sample using a descriptive reporting format for endometrial cytological diagnosis. 10,152 consecutive endometrial scrapings obtained in 13 different Japanese hospitals were analyzed. Cytological results were classified as 'negative for malignancy', 'atypical endometrial cells' (ATEC), 'endometrial hyperplasia', 'atypical endometrial hyperplasia' or 'malignant tumor'. ATEC was subclassified as 'ATEC, of undetermined significance' (ATEC-US) and 'ATEC, cannot exclude atypical endometrial hyperplasia or more' (ATEC-A). Cytological results were compared with the histological diagnosis as a gold standard. When the cytological result was 'negative for malignancy' and there was no subsequent histological examination, the case was considered a true negative when the endometrium was assessed as normal on transvaginal ultrasonography and there was no abnormal uterine bleeding. 1,083 cases in which histology was not performed, 557 cases of 'unsatisfactory specimen' and 76 cases of ATEC-US were excluded. In the remaining 8,436 cases, the sensitivity and specificity, positive predictive value and negative predictive value for detecting atypical endom...Continue Reading

Citations

Jan 29, 2014·Cytopathology : Official Journal of the British Society for Clinical Cytology·M FambriniS Guaschino
Apr 26, 2016·Cytopathology : Official Journal of the British Society for Clinical Cytology·Y NorimatsuT K Kobayashi
Sep 23, 2016·Diagnostic Cytopathology·Niki MargariPetros Karakitsos
Oct 6, 2018·Cancer Science·Motoki MatsuuraTsuyoshi Saito
Oct 3, 2018·Cytopathology : Official Journal of the British Society for Clinical Cytology·Hidetaka NomuraNobuhiro Takeshima
May 9, 2019·Cytopathology : Official Journal of the British Society for Clinical Cytology·Azusa NimuraTsutomu Tabata
Feb 21, 2018·Diagnostic Cytopathology·Akiko ShinagawaYoshida Yoshio
Nov 20, 2016·Cytopathology : Official Journal of the British Society for Clinical Cytology·S MunakataK Yanoh
Sep 2, 2019·Acta Cytologica·Yoshiaki NorimatsuFranco Fulciniti
Nov 17, 2021·Diagnostic Cytopathology·Satoru Munakata, Toshiya Yamamoto

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