New test to quantify lipid layer behavior in healthy subjects and patients with keratoconjunctivitis sicca

Cornea
M RolandoStefano Barabino

Abstract

Diagnostic procedures currently available to evaluate tear film lipid layer alterations are of limited application and do not provide quantitative results. The purpose of this prospective, case-control study was to develop a noninvasive test to measure tear lipid behavior in healthy subjects and patients with dry eye. The dynamic lipid layer interference patterns (DLIP) test was performed on 21 patients with dry eye and 21 age-matched controls. Subjects in the study and control groups were asked to perform 5 forced blinks and 10 consecutive nonforced blinks every 2 seconds to load lipids from the palpebral reservoir into the tear film. After recording the lipid layer interference patterns obtained with the Tearscope, a masked investigator counted the number of blinks to observe significant changes of shape, position, and number of waves of the interference patterns. Patients with dry eye were identified on the basis of the typical symptoms measured by a validated questionnaire (Ocular Surface Disease Index questionnaire score >10), Schirmer I test scores <10 mm/5 min, tear breakup time (TBUT) <7 seconds, and lissamine green conjunctival staining >4. Significant differences in Schirmer test, TBUT, and lissamine green were record...Continue Reading

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Citations

Jun 19, 2013·Experimental Eye Research·Igor A Butovich
May 22, 2010·Cornea·Christian ScifoMaurizio Rolando
Mar 12, 2013·Cornea·Carlos García-ResúaEva Yebra-Pimentel
Apr 3, 2012·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Dorota H Szczesna-Iskander, D Robert Iskander
Aug 13, 2014·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Carlos García-ResúaEva Yebra-Pimentel
Jul 12, 2014·IEEE Journal of Biomedical and Health Informatics·Beatriz RemeseiroNoelia Sánchez-Maroño
May 22, 2016·Computer Methods and Programs in Biomedicine·Beatriz RemeseiroManuel G Penedo
Apr 8, 2015·IEEE Journal of Biomedical and Health Informatics·Beatriz RemeseiroManuel G Penedo

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