New therapeutic approaches for resistant hypertension

Journal of Nephrology
Guido Grassi, Giuseppe Mancia

Abstract

In the past few years, 2 new procedures have been developed for the treatment of resistant hypertension: electrical stimulation of carotid baroreceptors and catheter-based renal denervation. Both of these procedures have a solid pathophysiological background, which is based on the evidence that carotid baroreceptors and renal nerves are involved in the pathogenesis of different forms of experimental hypertension, potentiating sympathetic cardiovascular influence and thus promoting the development and progression of elevated blood pressure values. This paper will review the results of the clinical trials performed so far making use of each of the 2 above-mentioned approaches. The pros and cons of each intervention as well as the questions that remain to be addressed in the future will also be discussed.

Citations

Nov 6, 2012·Expert Opinion on Pharmacotherapy·Guido Grassi
Sep 13, 2013·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Tetsuo NishikawaYoko Matsuzawa
Jan 2, 2015·Circulation. Cardiovascular Interventions·Kenichi SakakuraRenu Virmani
Feb 6, 2015·Circulation. Cardiovascular Interventions·Kenichi SakakuraRenu Virmani
Sep 23, 2014·Current Hypertension Reports·Erin L O'CallaghanJulian F R Paton
Jun 1, 2013·Pharmacotherapy·Steven M Smith
Oct 7, 2015·The Journal of Clinical Hypertension·Omid FatemiVasilios Papademetriou

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.