New Therapeutic Concept of NAD Redox Balance for Cisplatin Nephrotoxicity

BioMed Research International
Gi-Su OhHong-Seob So

Abstract

Cisplatin is a widely used chemotherapeutic agent for the treatment of various tumors. In addition to its antitumor activity, cisplatin affects normal cells and may induce adverse effects such as ototoxicity, nephrotoxicity, and peripheral neuropathy. Various mechanisms such as DNA adduct formation, mitochondrial dysfunction, oxidative stress, and inflammatory responses are closely associated with cisplatin-induced nephrotoxicity; however, the precise mechanism remains unclear. The cofactor nicotinamide adenine dinucleotide (NAD(+)) has emerged as a key regulator of cellular energy metabolism and homeostasis. Recent studies have demonstrated associations between disturbance in intracellular NAD(+) levels and clinical progression of various diseases through the production of reactive oxygen species and inflammation. Furthermore, we demonstrated that reduction of the intracellular NAD(+)/NADH ratio is critically involved in cisplatin-induced kidney damage through inflammation and oxidative stress and that increase of the cellular NAD(+)/NADH ratio suppresses cisplatin-induced kidney damage by modulation of potential damage mediators such as oxidative stress and inflammatory responses. In this review, we describe the role of NAD(+...Continue Reading

References

Jun 15, 1995·Clinica Chimica Acta; International Journal of Clinical Chemistry·M WernerR Nayar
May 15, 2001·Biological Signals and Receptors·J Bai, A I Cederbaum
Aug 30, 2001·Progress in Nucleic Acid Research and Molecular Biology·S M Cohen, S J Lippard
Oct 24, 2001·Cell·H VaziriR A Weinberg
Mar 15, 2002·Neuroreport·Issam A Ayoub, Kenneth I Maynard
Apr 16, 2002·Science·Ruslan Medzhitov, Charles A Janeway
Aug 22, 2002·Current Cancer Drug Targets·Arthur B PardeeChiang J Li
Mar 7, 2003·Molecular Cell·Brian J NorthEric Verdin
May 23, 2003·Cold Spring Harbor Symposia on Quantitative Biology·S ImaiL Guarente
Jun 7, 2003·The Journal of Infectious Diseases·Edward Abraham
Jul 17, 2003·American Journal of Physiology. Renal Physiology·Ganesan Ramesh, W Brian Reeves
Aug 21, 2003·Biochemical and Biophysical Research Communications·Weihai YingRaymond A Swanson
Sep 19, 2003·Seminars in Nephrology·Istvan Arany, Robert L Safirstein
Dec 5, 2003·Archives of Biochemistry and Biophysics·Roberta A Gottlieb
Dec 25, 2003·The Journal of Physiology·Cristine E Berry, Joshua M Hare
Feb 5, 2004·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Kori L Brewer, J Shane Hardin
Jun 29, 2004·Molecular Immunology·Anne F McGettrick, Luke A J O'Neill
Aug 25, 2004·The Journal of Biological Chemistry·Botond BánfiKarl-Heinz Krause
Nov 25, 2004·Journal of Neuroscience Research·Weihai YingRaymond A Swanson
Feb 11, 2005·American Journal of Physiology. Renal Physiology·Ganesan Ramesh, W Brian Reeves
Mar 25, 2005·Nature Reviews. Drug Discovery·Dong Wang, Stephen J Lippard
Mar 30, 2005·The Journal of Biological Chemistry·Gregory LisztLeonard Guarente
Aug 5, 2005·Molecular Biology of the Cell·Eriko MichishitaIzumi Horikawa
Jun 13, 2006·Cardiovascular Research·Miklós Geiszt
Sep 22, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shinjiro KanekoZhigang He
Oct 13, 2006·American Journal of Physiology. Renal Physiology·Ganesan RameshW Brian Reeves
Dec 13, 2006·Trends in Biochemical Sciences·Peter BelenkyCharles Brenner
Feb 13, 2007·Current Opinion in Nephrology and Hypertension·Christopher Y LuJianlin Chen
Mar 7, 2007·Annals of Biomedical Engineering·Charles I JonesB Rita Alevriadou

❮ Previous
Next ❯

Citations

Oct 25, 2016·Oxidative Medicine and Cellular Longevity·Shreesh OjhaMohanraj Rajesh
Oct 28, 2019·International Journal of Molecular Sciences·Daniela Maria TanaseCiprian Rezus
Sep 18, 2020·Antioxidants·Adrienne Bushau-SprinkleEleanor Lederer
Jul 26, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Eglal MahgoubMohanraj Rajesh

❮ Previous
Next ❯

Methods Mentioned

BETA
acetylation

Related Concepts

Related Feeds

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Cancer Metabolism: Therapeutic Targets

Targeting the mechanisms by which cancer cells acquire energy for metabolic needs is a therapeutic target. Discover the latest research on cancer metabolism and therapeutic targets.