New therapeutic options opened by the molecular classification of gastric cancer

World Journal of Gastroenterology : WJG
Mihaela Chivu-EconomescuCarmen C Diaconu

Abstract

Gastric cancer (GC) is one of the most lethal and aggressive cancers, being the third cause of cancer related death worldwide. Even with radical gastrectomy and the latest generation of molecular chemotherapeutics, the numbers of recurrence and mortality remains high. This is due to its biological heterogeneity based on the interaction between multiple factors, from genomic to environmental factors, diet or infections with various pathogens. Therefore, understanding the molecular characteristics at a genomic level is critical to develop new treatment strategies. Recent advances in GC molecular classification provide the unique opportunity to improve GC therapy by exploiting the biomarkers and developing novel targeted therapy specific to each subtype. This article highlights the molecular characteristics of each subtype of gastric cancer that could be considered in shaping a therapeutic decision, and also presents the completed and ongoing clinical trials addressed to those targets. The implementation of the novel molecular classification system will allow a preliminary patient selection for clinical trials, a mandatory issue if it is desired to test the efficacy of a certain inhibitor to the given target. This will represent a...Continue Reading

References

May 15, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Y D JungL M Ellis
Apr 12, 2005·Drugs of Today·Joanne Harding, Barbara Burtness
Jul 11, 2006·The New England Journal of Medicine·David Cunningham MAGIC Trial Participants
Jan 19, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G ValabregaM Aglietta
Aug 19, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Wells A Messersmith, Manuel Hidalgo
Oct 6, 2007·Immunologic Research·George J Weiner
Mar 31, 2009·Biochimica Et Biophysica Acta·R KarlssonCord Brakebusch
Oct 22, 2009·British Journal of Clinical Pharmacology·Eline A Dubois, Adam F Cohen
Aug 1, 2005·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Won Ki KangChaehwa Park
Feb 25, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Peter J Houghton
Mar 31, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jae Yong ChoJu-Seog Lee
Sep 8, 2011·International Journal of Cancer. Journal International Du Cancer·Ji Yeong AnSung Hoon Noh
Jan 14, 2012·Expert Opinion on Therapeutic Targets·Parthasarathy SeshacharyuluSurinder K Batra
Jan 25, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michael R GreenMargaret A Shipp
Jun 22, 2012·Frontiers in Oncology·Thuy Vu, Francois X Claret
Sep 15, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Masanori TerashimaUNKNOWN ACTS-GC Group
Jan 24, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Giovanni CorsoCarla Oliveira
Apr 19, 2013·The Lancet Oncology·Florian LordickUNKNOWN Arbeitsgemeinschaft Internistische Onkologie and EXPAND Investigators
May 8, 2013·PloS One·Cristina Balbás-MartínezFrancisco X Real
May 31, 2013·Future Oncology·Roopma WadhwaJaffer A Ajani
Jul 25, 2013·Proceedings of the National Academy of Sciences of the United States of America·Mark MerchantDaniel G Yansura
Sep 18, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Atsushi OhtsuEric Van Cutsem
Nov 5, 2013·European Journal of Cell Biology·Dean ThumkeoShuh Narumiya
Nov 21, 2013·Journal of Cellular and Molecular Medicine·Meng Ling ChoongMay Ann Lee
Feb 22, 2014·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Lin ShenYongzhe Piao
Mar 13, 2014·Cancer Biology & Therapy·Ren-Chin WuIe-Ming Shih
May 13, 2014·Nature Genetics·Miwako KakiuchiShumpei Ishikawa
May 29, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Taroh SatohYung-Jue Bang
Jul 16, 2014·Cancer Cell·Jin ZhouAdam J Bass

❮ Previous
Next ❯

Citations

Apr 25, 2020·World Journal of Gastroenterology : WJG·Mihaela Chivu-EconomescuCarmen Cristina Diaconu
May 23, 2019·World Journal of Gastroenterology : WJG·Laura NeculaMihaela Chivu-Economescu
Jun 27, 2020·World Journal of Gastroenterology : WJG·Laura NeculaMihaela Chivu-Economescu
Jul 30, 2020·Current Treatment Options in Oncology·Timil H Patel, Michael Cecchini
Apr 23, 2020·Archives of Pathology & Laboratory Medicine·Zainab I Alruwaii, Elizabeth A Montgomery

❮ Previous
Next ❯

Methods Mentioned

BETA
GTPase
GTPases

Clinical Trials Mentioned

NCT02335411
NCT02370498
NCT02494583
NCT03221426
NCT03006705
NCT02872116
NCT02746796
NCT02267343
NCT02625623
NCT02625610

Software Mentioned

AVAGAST

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Current Treatment Options in Oncology
Elizabeta C Popa, Manish A Shah
Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC
Robert L Reid
Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Mengqi YangPeng Huang
© 2022 Meta ULC. All rights reserved