New therapeutic strategies in perinatal stroke

Current Drug Targets. CNS and Neurological Disorders
Walter BalduiniMauro Cimino

Abstract

Perinatal stroke represents an important cause of severe neurological deficits that span the individual's lifetime, including delayed mental and motor development, epilepsy and major cognitive deficits. Most strokes occurring in term births, infants and children can be caused by thromboembolism from intracranial and extracranial vessels and are associated with a variety of risk factors such as birth asphyxia, cardiac diseases, blood disorders, maternal disorders, trauma. Animal models of perinatal stroke have been developed to examine the nature and the time course of the events occurring after the ischemic insult and the possible therapeutic strategies useful in reducing ischemic damage. The present article addresses the potential pharmacological treatments targeting the inflammatory process and apoptotic cell death, with a specific emphasis on the emerging role of statins as neuroprotective agents in perinatal stroke. As a prelude, we will also review advances in our understanding on the mechanisms underlying the hypoxic-ischemic reperfusion injury in the newborn.

Citations

Mar 2, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Michael IbrahimCesare M Terracciano
Sep 1, 2006·Future Cardiology·Adam Kirton, Gabrielle Deveber
Jun 30, 2009·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·V C PimentelM B Moretto
Jan 24, 2009·Clinics in Perinatology·Alan R Barnette, Terrie E Inder
Feb 17, 2009·Pediatric Neurology·Adam Kirton, Gabrielle deVeber
Oct 16, 2007·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Mir Ahamed Hossain
Feb 22, 2008·Journal of Pineal Research·Silvia CarloniWalter Balduini
Jun 17, 2006·Biochemical and Biophysical Research Communications·Da Yong LeeByung Kwan Jin
Oct 3, 2013·Neurobiology of Disease·Orhan AltayJohn H Zhang
Oct 17, 2012·Neurobiology of Disease·Md Al RahimMir Ahamed Hossain
Feb 1, 2008·Current Protocols in Toxicology·Silvia Carloni, Walter Balduini
Aug 31, 2018·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·María Eugenia BogettiSara Fiszer de Plazas
Jul 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Myung-Soon YangEunhye Joe

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