New therapeutic targets in cancer: the epigenetic connection.

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
Michel Herranz, Manel Esteller

Abstract

Cancer is an epigenetic disease, a combination of DNA modifications, chromatin organization and variations in its associated proteins, configure a new entity that regulates gene function throughout methylation, acetylation and chromatin remodelling. Irregular de novo DNA methylation, mainly promoter hypermethylation, histone deacetylation or methylation are important means for the transcriptional repression of cancer-associated genes. Reverse these epigenetic processes restoring normal expression of malignancy- preventing-genes has consequently become a new therapeutic target in cancer treatment. Aberrant patterns of epigenetic modifications will be, in a near future, crucial parameters in cancer diagnosis, prognosis and therapy.

References

Jun 1, 1990·Cell·E R Fearon, B Vogelstein
Dec 20, 1990·Nature·B Vogelstein
Jul 15, 1999·Nature Structural Biology·F Winston, C D Allis
Jan 19, 2000·Nature·B D Strahl, C D Allis
Feb 26, 2000·Carcinogenesis·K D Robertson, P A Jones
Aug 11, 2001·Science·T Jenuwein, C D Allis
Oct 5, 2001·Molecular Cell·C M Pickart
Dec 26, 2001·Human Molecular Genetics·M EstellerJ G Herman
Mar 21, 2002·Nature Reviews. Cancer·P MarksW K Kelly
May 16, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lewis R SilvermanJames F Holland
Nov 7, 2002·Cell·Bryan M Turner
Dec 17, 2002·Molecular and Cellular Biology·Yutaka KondoJean-Pierre J Issa
Feb 7, 2003·Current Drug Metabolism·Ana Villar-Garea, Manel Esteller
Mar 6, 2003·Journal of the National Cancer Institute·Jonathan C ChengEric U Selker
Oct 28, 2003·Proceedings of the National Academy of Sciences of the United States of America·Yuzuru Shiio, Robert N Eisenman
Feb 21, 2004·Current Topics in Developmental Biology·Judith K Davie, Sharon Y R Dent
Aug 25, 2004·Cancer Cell·Jonathan C ChengPeter A Jones

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Citations

Dec 1, 2006·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·M Dolore Delgado, Javier León
Apr 2, 2011·The Journal of Biological Chemistry·Sayyed K ZaidiGary S Stein
Apr 17, 2007·Carcinogenesis·So Young Kim, William C Hahn
Apr 17, 2013·Journal of Cellular Physiology·Sayyed K ZaidiGary S Stein
Sep 9, 2008·The International Journal of Biochemistry & Cell Biology·Astrid SpannhoffManfred Jung
May 29, 2007·Progress in Retinal and Eye Research·Susanne BinderCarl Glittenberg
Jun 18, 2015·Computational and Structural Biotechnology Journal·Federico Andreoli, Alberto Del Rio
May 15, 2007·The International Journal of Biochemistry & Cell Biology·Joern LewinReinhold Wasserkort
May 19, 2009·Cell Biology International·L P Shvachko
Sep 13, 2007·Molecular Carcinogenesis·Colleen C SpurlingCharles Giardina
May 27, 2009·Expert Opinion on Therapeutic Targets·Erik W Bush, Timothy A McKinsey
Apr 17, 2021·Cellular Reprogramming·Muhmmad AtifQaisar Raza

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