New therapeutics in rheumatoid arthritis

Rheumatic Diseases Clinics of North America
Christine Savage, E William St Clair

Abstract

Rheumatoid arthritis (RA) is a systemic disorder characterized predominately by a chronic inflammatory polyarthritis, with frequent progression to joint destruction and disability. Radiographic joint damage develops in as many as 75% of patients within the first 2 years of disease. For this reason, current RA treatment approaches have focused on early intensive therapy with multiple disease-modifying antirheumatic drugs. The approval of new drugs for this indication has expanded the number of therapeutic options that can potentially allow for tight control of the inflammatory process.

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Citations

Feb 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·Thomas CalzasciaTak W Mak
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Jan 23, 2008·Expert Opinion on Therapeutic Targets·Charles J Malemud, Andrew H Miller
Jul 6, 2014·Current Diabetes Reports·Paolo Monti, Ezio Bonifacio

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