New therapies for dedifferentiated papillary thyroid cancer

International Journal of Molecular Sciences
Poupak FallahiAlessandro Antonelli

Abstract

The number of thyroid cancers is increasing. Standard treatment usually includes primary surgery, thyroid-stimulating hormone suppressive therapy, and ablation of the thyroid remnant with radioactive iodine (RAI). Despite the generally good prognosis of thyroid carcinoma, about 5% of patients will develop metastatic disease, which fails to respond to RAI, exhibiting a more aggressive behavior. The lack of specific, effective and well-tolerated drugs, the scarcity of data about the association of multi-targeting drugs, and the limited role of radioiodine for dedifferentiated thyroid cancer, call for further efforts in the field of new drugs development. Rearranged during transfection (RET)/papillary thyroid carcinoma gene rearrangements, BRAF (B-RAF proto-oncogene, serine/threonine kinase) gene mutations, RAS (rat sarcoma) mutations, and vascular endothelial growth factor receptor 2 angiogenesis pathways are some of the known pathways playing a crucial role in the development of thyroid cancer. Targeted novel compounds have been demonstrated to induce clinical responses and stabilization of disease. Sorafenib has been approved for differentiated thyroid cancer refractory to RAI.

References

Jan 1, 1990·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·W SchroyensJ Klastersky
Feb 1, 1995·Thyroid : Official Journal of the American Thyroid Association·A AntonelliL Baschieri
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Sep 23, 2000·Nature·P Carmeliet, R K Jain
Dec 14, 2001·Laboratory Investigation; a Journal of Technical Methods and Pathology·R CorviG Romeo
Feb 14, 2003·Lancet·Steven I Sherman
Feb 18, 2003·Endocrine Reviews·Orsolya DohánNancy Carrasco
May 3, 2003·The Journal of Clinical Endocrinology and Metabolism·Marina N NikiforovaYuri E Nikiforov
Jul 12, 2003·Thyroid : Official Journal of the American Thyroid Association·Alessandro AntonelliEle Ferrannini
Oct 23, 2003·Endocrine Reviews·Helen E TurnerJohn A H Wass
Dec 30, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Bradley A SchiffJeffrey N Myers
Jul 20, 2005·Current Pharmaceutical Design·Sabrina M CoelhoDenise P Carvalho
Jul 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hope S RugoGeorge Wilding
Oct 8, 2005·Cancer Treatment and Research·Orsolya Dohán, Nancy Carrasco
Nov 10, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Susana B BravoClara V Alvarez
Jan 7, 2006·Nature Reviews. Cancer·Saverio Minucci, Pier Giuseppe Pelicci
Mar 2, 2006·Journal of the National Cancer Institute·Francesca CarlomagnoMassimo Santoro
Jun 21, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Akira InoueToshihiro Nukiwa
Jul 20, 2006·Endocrine Reviews·Jan Willem B de GrootRobert M W Hofstra
Sep 27, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Quang T LuongH Phillip Koeffler
Feb 3, 2007·The Lancet Oncology·Eric Baudin, Martin Schlumberger
Mar 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Laura Q M Chow, S Gail Eckhardt
Mar 31, 2007·Circulation Research·Laurent LamaliceJacques Huot
Jun 5, 2007·Thyroid : Official Journal of the American Thyroid Association·Alessandro AntonelliEle Ferrannini
Jun 15, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lee S RosenRoy S Herbst
Jun 21, 2007·The Journal of Clinical Endocrinology and Metabolism·J W B de GrootE E Voest
Jul 28, 2007·European Journal of Endocrinology·Karin Frank-RaueFriedhelm Raue
Sep 25, 2007·Arquivos brasileiros de endocrinologia e metabologia·Denise P Carvalho, Andrea C F Ferreira
Oct 12, 2007·Expert Opinion on Pharmacotherapy·Brian I Rini
Oct 17, 2007·Archives of Otolaryngology--head & Neck Surgery·Jay Patrick LopezWeg M Ongkeko
Oct 31, 2007·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Matthew J ProvenzanoFrederick E Domann

❮ Previous
Next ❯

Citations

Dec 3, 2015·Journal of Medicinal Chemistry·Guido BoldAmanda Littlewood-Evans
Feb 18, 2016·Journal of Thyroid Research·Toral P KobawalaNandita R Ghosh
Dec 5, 2015·Frontiers in Endocrinology·Silvia Martina FerrariAlessandro Antonelli
Jul 17, 2016·Endocrine-related Cancer·Giuseppe PalladinoMatteo Landriscina
Oct 25, 2016·International Journal of Molecular Sciences·Paola CariaTinuccia Dettori
Aug 21, 2018·Expert Opinion on Therapeutic Targets·Jason TasoulasStamatios Theocharis
Nov 2, 2018·Annals of the New York Academy of Sciences·Francesca PistollatoMaurizio Battino
Dec 16, 2017·Expert Review of Anticancer Therapy·Alessandro AntonelliPoupak Fallahi
Feb 6, 2018·Therapeutic Advances in Medical Oncology·Laurence FaugerasLionel D'Hondt
Mar 21, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Lei FangWei Xu

❮ Previous
Next ❯

Methods Mentioned

BETA
dissection
Histone
Transfection
acetylation
imaging techniques
xenograft
xenografts
biopsies
glycosylation

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.