New therapies for systemic lupus erythematosus: cellular targets

Rheumatic Diseases Clinics of North America
R John LooneyIñaki Sanz

Abstract

Antilymphocyte antibodies have been widely used in oncology and transplantation and are now being tested in autoimmune diseases. For systemic lupus erythematosus, anti-B-cell antibodies are furthest along in development. This article discusses the B-cell abnormalities found in systemic lupus erythematosus and the clinical and immunologic effects of anti-B-cell therapies.

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Oct 5, 2007·Current Rheumatology Reports·Rajan RavikumarR John Looney
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