PMID: 11911177Mar 26, 2002Paper

New therapies for the pregnant patient with diabetes

Diabetes Technology & Therapeutics
Y Y El-Sayed, D J Lyell

Abstract

Gestational diabetes complicates 3-5% of pregnancies. Of diabetes seen during pregnancy, 10% is pregestational and the remaining 90% represents gestational diabetes. (1,2) Pregnancy in women with pregestational diabetes is especially high risk. Spontaneous abortion, preterm labor, congenital malformations, preeclampsia, macrosomia, birth injury, and cesarean section are all increased in these pregnancies. Deterioration of maternal health during pregnancy, especially in the setting of diabetes-induced end-organ disease, is a real concern. Vigilant surveillance and management of associated disorders such as retinopathy, nephropathy, and chronic hypertension are required. During the preinsulin era, maternal and perinatal mortality in pregnancies complicated by pregestational diabetes was approximately 50%. (1,2) Although modern obstetrical management and the appropriate use of insulin have dramatically improved maternal-fetal outcomes, pregnant patient with diabetes remains at increased risk for complications. There is no doubt that optimizing maternal glucose control is a key element in avoiding established perinatal risks. The most effective means to accomplish this control are topics of active research. Further, hormonal change...Continue Reading

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Citations

Jan 29, 2011·Reproduction : the Official Journal of the Society for the Study of Fertility·Pan-Pan ChengZhong-Quan Qi
Mar 17, 2010·Mitochondrion·Qiang Wang, Kelle H Moley
Mar 14, 2012·Annals of the New York Academy of Sciences·David A AlbertEvanthia Lalla
Apr 10, 2003·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·R Preece, L Jovanovic
Nov 6, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity·Manuel Doblado, Kelle H Moley

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