New thin-film surface electrode array enables brain mapping with high spatial acuity in rodents

Scientific Reports
W S KonerdingP Baumhoff

Abstract

In neuroscience, single-shank penetrating multi-electrode arrays are standard for sequentially sampling several cortical sites with high spatial and temporal resolution, with the disadvantage of neuronal damage. Non-penetrating surface grids used in electrocorticography (ECoG) permit simultaneous recording of multiple cortical sites, with limited spatial resolution, due to distance to neuronal tissue, large contact size and high impedances. Here we compared new thin-film parylene C ECoG grids, covering the guinea pig primary auditory cortex, with simultaneous recordings from penetrating electrode array (PEAs), inserted through openings in the grid material. ECoG grid local field potentials (LFP) showed higher response thresholds and amplitudes compared to PEAs. They enabled, however, fast and reliable tonotopic mapping of the auditory cortex (place-frequency slope: 0.7 mm/octave), with tuning widths similar to PEAs. The ECoG signal correlated best with supragranular layers, exponentially decreasing with cortical depth. The grids also enabled recording of multi-unit activity (MUA), yielding several advantages over LFP recordings, including sharper frequency tunings. ECoG first spike latency showed highest similarity to superfici...Continue Reading

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Citations

Feb 7, 2020·Methods and Protocols·Marco CelottoPier Stanislao Paolucci
Jun 3, 2020·Journal of Neural Engineering·Luigi PavoneRoberto Senesi
Mar 18, 2020·Frontiers in Neuroscience·John HermizVikash Gilja
Dec 6, 2020·Scientific Reports·Keivan KeramatzadehAmir M Sodagar
Feb 3, 2021·Journal of Neural Engineering·Taro KaijuTakafumi Suzuki
May 1, 2021·Nanomaterials·Katharina ForemnyTheodor Doll
Apr 30, 2021·Frontiers in Neuroscience·Maryam HejaziDavid J Garrett
Jun 19, 2021·Nature Nanotechnology·Christina M TringidesDavid J Mooney
Jun 29, 2021·Trends in Neurosciences·Linette Liqi TanRohini Kuner

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Methods Mentioned

BETA
cochlear implants

Software Mentioned

Matlab
MUA
AudiologyLab

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