PMID: 8610070Aug 1, 1995Paper

New thioureas and related substances intended for melanoma targeting

Pigment Cell Research
U Mårs, B S Larsson

Abstract

Thiouracil and a few related drugs are known to be melanoma-seeking agents owing to specific incorporation into nascent melanin. The melanin-affinic properties are apparently due to binding to intermediates, preferably dopaquinone, produced in the melanin synthetic pathway by tyrosinase-catalysed oxidation of tyrosine. In the present paper, in vitro screening methods have been used for the identification of possible melanoma seekers according to the above principle. The binding of test substance to dopaquinone suppressed dopachrome formation by the withdrawal of dopaquinone from the reaction of the mixture, and the decrease in dopachrome concentration was monitored spectrophotometrically at 475 nm. In order to eliminate false results caused by tyrosinase inhibition, which also will decrease the dopachrome concentration, the oxygen consumption was followed potentiometrically. To avoid the effect of tyrosinase inhibition on dopachrome formation, additional experiments with autoxidation of L-dopa in the presence of test substance were performed. Of the 22 substances (mainly thioureylenes and thioamides) studied, 4,5,6-triamino-2(H)- pyrimidinehtionsulfate, trithiocyanuric acid, 2-thiouracil, 6-methyl-2-thiouracil, and 4- amino-2-m...Continue Reading

References

Apr 1, 1979·British Journal of Cancer·L DenckerM Yokota
Jun 1, 1991·Melanoma Research·B S Larsson
Nov 1, 1991·Melanoma Research·K TsukamotoV J Hearing
Apr 1, 1986·The Biochemical Journal·A Andrawis, V Kahn
Jun 1, 1988·The Journal of Investigative Dermatology·K YamadaS Ullberg
Jan 1, 1986·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·N A FrankenE K Pauwels
Jul 14, 1967·Science·J K Palmer, J B Roberts
Aug 1, 1981·Acta Pharmacologica Et Toxicologica·L DenckerM Yokota
Jan 1, 1983·European Journal of Nuclear Medicine·A van LangeveldeE K Pauwels
Feb 1, 1983·Acta Pharmacologica Et Toxicologica·K OlanderL Dencker
Nov 15, 1994·The Biochemical Journal·S Naish-ByfieldP A Riley
Aug 18, 1994·Biochimica Et Biophysica Acta·A PalumboV J Hearing
Jun 1, 1993·Pigment Cell Research·B S Larsson

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Citations

Jan 11, 2001·Nuclear Medicine and Biology·U MårsA Sundin
Feb 24, 2011·The Journal of Chemical Physics·Xiang LiKit H Bowen
Jul 22, 2014·International Journal of Molecular Sciences·Seung-Hwa BaekSang-Han Lee
Oct 30, 2007·Bioorganic & Medicinal Chemistry Letters·Juris P GermanasJoseph M Ready
Apr 9, 2005·Rapid Communications in Mass Spectrometry : RCM·Grazyna Bartkowiak
Sep 3, 2003·Pigment Cell Research·Patrick A Riley
Mar 21, 2007·Pigment Cell Research·Tae-Young ChoiTae-Jin Yoon
Jul 16, 2015·Pigment Cell & Melanoma Research·Marco d'IschiaShosuke Ito
Jun 26, 2012·The Journal of Physical Chemistry. a·Jing ChenJ V Ortiz
May 3, 2014·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·R Singh, R A Yadav
Jul 29, 1998·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·L LapinskiJ Leszczyński
Dec 20, 1996·Journal of Medicinal Chemistry·A NapolitanoG Prota

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