New treatment of acute hypoxemic respiratory failure: noninvasive pressure support ventilation delivered by helmet--a pilot controlled trial

Critical Care Medicine
Massimo AntonelliR Proietti

Abstract

To assess the efficacy of noninvasive pressure support ventilation (NPSV) using a new special helmet as first-line intervention to treat patients with hypoxemic acute respiratory failure (ARF), in comparison to NPSV using standard facial mask. Prospective clinical pilot investigation with matched control group in three intensive care units of university hospitals. Thirty-three consecutive patients without chronic obstructive pulmonary disease and with hypoxemic ARF (defined as severe dyspnea at rest, respiratory rate >30 breaths/min, PaO2:FiO2 < 200, and active contraction of the accessory muscles of respiration) were enrolled. Each patient treated with NPSV by helmet was matched with two controls with ARF treated with NPSV via a facial mask, selected by simplified acute physiologic score II, age, PaO2/FiO2, and arterial pH at admission. Primary end points were the improvement of gas exchanges, the need for endotracheal intubation, and the complications related to NPSV. The 33 patients and the 66 controls had similar characteristics at baseline. Both groups improved oxygenation after NPSV. Eight patients (24%) in the helmet group and 21 patients (32%) in the facial mask group (p = .3) failed NPSV and were intubated. No patients...Continue Reading

References

Feb 1, 1989·The American Review of Respiratory Disease·Laurent BrochardF Lemaire
Oct 1, 1985·Archives of Surgery·R J GorisJ S Gimbrère
Mar 1, 1994·American Journal of Respiratory and Critical Care Medicine·G R BernardR Spragg
Sep 28, 1995·The New England Journal of Medicine·Laurent BrochardF Lemaire
Jan 1, 1994·Chest·Massimo AntonelliA Gasparetto
Sep 1, 1996·Clinics in Chest Medicine·Gianfranco Umberto Meduri
Sep 2, 1999·Intensive Care Medicine·Edoardo CalderiniCesare Gregoretti
Jan 14, 2000·JAMA : the Journal of the American Medical Association·Massimo AntonelliGianfranco Umberto Meduri
Mar 11, 2000·American Journal of Respiratory and Critical Care Medicine·T J MartinM H Sanders
Apr 29, 2000·Monaldi Archives for Chest Disease = Archivio Monaldi Per Le Malattie Del Torace·Giorgio ContiMonica Rocco

Citations

Nov 23, 2006·Intensive Care Medicine·Nicolò PatronitiAntonio Pesenti
Apr 19, 2008·Intensive Care Medicine·Francesco MojoliAntonio Braschi
May 7, 2008·Intensive Care Medicine·Fabrizio RaccaV Marco Ranieri
Apr 7, 2007·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Dean Hess
Apr 14, 2012·British Journal of Anaesthesia·A SchreiberA Carlucci
Apr 9, 2013·British Journal of Anaesthesia·Michele CarronAntonio M Esquinas
Sep 16, 2003·Critical Care Medicine·Guilherme P P SchettinoRobert M Kacmarek
Oct 16, 2004·Critical Care Medicine·Paolo TacconeLuca M Bigatello
Oct 16, 2004·Critical Care Medicine·Nicholas S Hill
Aug 4, 2006·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Daniela CodazziRoberto Fumagalli
Sep 9, 2006·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Werther Brunow de Carvalho, Cíntia Johnston
Apr 23, 2009·Critical Care Medicine·Frédéric VargasLaurent Brochard
May 19, 2009·Critical Care Medicine·Stefano Nava, Paolo Navalesi
Oct 2, 2009·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Giovanna ChidiniPaolo Pelosi
May 18, 2013·Critical Care : the Official Journal of the Critical Care Forum·Antonio M Esquinas RodriguezDavide Chiumello
Feb 8, 2005·Critical Care : the Official Journal of the Critical Care Forum·Massimo AntonelliLuca Montini
Apr 23, 2008·Critical Care : the Official Journal of the Critical Care Forum·Davide ChiumelloLuciano Gattinoni
Jun 9, 2009·Critical Care : the Official Journal of the Critical Care Forum·Onnen MoererPaolo Pelosi
Jan 7, 2014·Critical Care : the Official Journal of the Critical Care Forum·Rosanna VaschettoSamir Jaber
Mar 7, 2014·Medizinische Klinik, Intensivmedizin und Notfallmedizin·R Doppler
Mar 15, 2006·Der Internist·T Wagner
May 24, 2011·Medicina intensiva·A Belenguer-MuncharazA Ferrándiz-Sellés
Jan 25, 2011·Enfermería intensiva·S Pérez GonzálezM L Vázquez Álvarez
Feb 3, 2009·The Journal of Thoracic and Cardiovascular Surgery·Luca S De SantoMaurizio Cotrufo
Oct 3, 2008·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·O Noizet-YverneauP Morville
Dec 18, 2007·Journal of Clinical Anesthesia·Michele CarronCarlo Ori
Oct 23, 2010·Pediatric Pulmonology·A Vivanco-AllendeA Medina

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Separation Anxiety

Separation anxiety is a type of anxiety disorder that involves excessive distress and anxiety with separation. This may include separation from places or people to which they have a strong emotional connection with. It often affects children more than adults. Here is the latest research on separation anxiety.

KIF1A Associated Neurological Disorder

KIF1A associated neurological disorder (KAND) is a rare neurodegenerative condition caused by mutations in the KIF1A gene. KAND may present with a wide range and severity of symptoms including stiff or weak leg muscles, low muscle tone, a lack of muscle coordination and balance, and intellectual disability. Find the latest research on KAND here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.