New treatments for antiphospholipid syndrome

Rheumatic Diseases Clinics of North America
D Erkan, M D Lockshin

Abstract

Challenges in new drug development for APS include the controversy about the strength of association between aPL and thrombotic events, and unknown mechanism of aPL-induced thrombosis. In the long-term management of patients who have APS, controlled studies with warfarin alternatives (such as antiplatelet agents), the new anticoagulant agents (such as direct and indirect thrombin inhibitors), and newer therapeutic agents are vital. It is highly possible that the current "antithrombotic" approach to patients who are aPL-positive will be replaced by a "more specifically targeted, anti-inflammatory or immunomodulatory" approach in the future.

References

Aug 15, 1992·Annals of Internal Medicine·M H Rosove, P M Brewer
Aug 1, 1994·Lupus·P G de Groot, R H Derksen
Apr 13, 1995·The New England Journal of Medicine·M A KhamashtaG R Hughes
Jun 1, 1994·Thrombosis Research·V JancinováM Petríková
Mar 20, 1998·Arthritis and Rheumatism·A TedeschiA Miadonna
Apr 16, 1998·American Heart Journal·J J FergusonC Vassanelli
May 19, 2000·Rheumatology·Y ShererY Shoenfeld
Jan 12, 2002·Circulation Research·Jacob H Rand
Mar 15, 2003·Obstetrics and Gynecology·Rodney D Franklin, William H Kutteh
Jun 26, 2003·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·R ZaidanS Al Rajeh
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·J Arnout, J Vermylen
Sep 17, 2003·Circulation·Scott KinlayUNKNOWN Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering Study Investigators
Sep 26, 2003·Transfusion·Irina Knezevic-Maramica, Margot S Kruskall
Oct 18, 2003·The Journal of Allergy and Clinical Immunology·Holly Conway Brown, Zuhair K Ballas
Oct 29, 2003·Neurology·D TanneUNKNOWN NINDS rt-PA Stroke Study Group
Oct 31, 2003·The New England Journal of Medicine·Sam SchulmanUNKNOWN THRIVE III Investigators
Dec 16, 2003·Arthritis and Rheumatism·Doruk ErkanRonald A Asherson
Jan 14, 2004·Seminars in Thrombosis and Hemostasis·Lori-Ann Linkins, Jeffrey I Weitz
Jan 20, 2004·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Jeffrey I Weitz, Mark A Crowther

❮ Previous
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Citations

Jun 17, 2008·Journal des maladies vasculaires·C Le HelloJ Constans
Dec 19, 2008·Arthritis Research & Therapy·Gerard Espinosa, Ricard Cervera
Jul 19, 2011·Journal of the American Academy of Dermatology·Tamihiro KawakamiYoshinao Soma
Aug 3, 2010·Journal of the American Academy of Dermatology·Tamihiro Kawakami, Yoshinao Soma
Mar 6, 2007·Seminars in Nephrology·Michael J FischerJerrold S Levine
Dec 4, 2008·Advances in Pediatrics·Alice Chang HoftmanE Richard Stiehm
Oct 16, 2007·Rheumatic Diseases Clinics of North America·Angelo Ravelli, Alberto Martini
Mar 15, 2016·The Journal of Dermatology·Manabu FujimotoUNKNOWN Wound/Burn Guidelines Committee
Apr 22, 2009·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Maria BortolatiAmelia Ruffatti
Jun 30, 2009·Journal of Autoimmunity·Josephine I Tuthill, Munther A Khamashta
Mar 1, 2006·Rheumatic Diseases Clinics of North America·Doruk Erkan, Michael D Lockshin
Apr 7, 2007·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Nathan G LaFayetteGail M Annich
Nov 4, 2006·Clinical Obstetrics and Gynecology·D Ware Branch, Alexandra Grosvenor Eller
Mar 1, 2008·Expert Review of Clinical Immunology·Silvia S Pierangeli
Jan 22, 2020·The Journal of Dermatology·Manabu FujimotoUNKNOWN Japanese Dermatological Association Guidelines
Mar 17, 2009·Expert Opinion on Pharmacotherapy·Gerard Espinosa, Ricard Cervera

❮ Previous
Next ❯

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