New Trends for Antimalarial Drugs: Synergism between Antineoplastics and Antimalarials on Breast Cancer Cells.

Biomolecules
Diana Duarte, Nuno Vale

Abstract

Chemotherapy plays a key role in breast cancer therapy, but drug resistance and unwanted side effects make the treatment less effective. We propose a new combination model that combines antineoplastic drugs and antimalarials for breast cancer therapy. Cytotoxic effects of two antineoplastic agents alone and in combination with several antimalarials on MCF-7 tumor cell line was evaluated. Different concentrations in a fixed ratio were added to the cultured cells and incubated for 48 h. Cell viability was evaluated using MTT and SRB assays. Synergism was evaluated using the Chou-Talalay method. The results indicate doxorubicin (DOX) and paclitaxel (PTX) alone at concentrations of their IC50 and higher are cell growth inhibitors. Mefloquine, artesunate, and chloroquine at concentrations of their IC50 demonstrate anti-cancer activity. In combination, almost all antimalarials demonstrate higher ability than DOX and PTX alone to decrease cell viability at concentrations of IC50 and lower than their IC50. The combination of chloroquine, artesunate and mefloquine with DOX and PTX was synergic (CI < 1). The combination of DOX and mefloquine after 48 h incubation demonstrated the highest cytotoxicity against MCF-7 cells, and the combinat...Continue Reading

References

Jun 1, 1996·Lancet·P D RadloffP G Kremsner
May 31, 2002·Expert Opinion on Pharmacotherapy·Tarek M Mekhail, Maurie Markman
Jul 18, 2002·Nature Reviews. Drug Discovery·Joshua H Atkins, Leland J Gershell
Dec 23, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J Kevin BairdStephen L Hoffman
Apr 2, 2004·Nature Reviews. Cancer·Mary Ann Jordan, Leslie Wilson
Oct 21, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J Kevin Baird, Stephen L Hoffman
May 27, 2005·The Journal of Biological Chemistry·Michael W MatherAkhil B Vaidya
Jan 18, 2006·Bioorganic & Medicinal Chemistry·Chuandong FanJunying Miao
Dec 18, 2008·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Pei-du JiangYu-quan Wei
Jan 29, 2009·Integrative Cancer Therapies·Karen Y Wonders, Beverly S Reigle
Aug 18, 2009·Advanced Drug Delivery Reviews·María J VicentRuth Duncan
Mar 12, 2010·Journal of the National Cancer Institute·Olivia PaganiUNKNOWN ESO-MBC Task Force
Mar 20, 2010·Clinical Pharmacology and Therapeutics·F StegmeierM Dorsch
Nov 5, 2010·Pharmacogenetics and Genomics·Caroline F ThornRuss B Altman
May 19, 2011·Nature Reviews. Clinical Oncology·Filip JankuRazelle Kurzrock
Jun 22, 2012·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Jung-Hye ChoiYoung Yiul Lee
Dec 15, 2012·Current Drug Discovery Technologies·Murat Cokol
Jan 16, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Li-Xia HuYue-Yin Pan
May 15, 2013·Autophagy·Francois Lamoureux, Amina Zoubeidi
Jul 31, 2013·Immunology Letters·Rodolfo ThoméLiana Verinaud
Jan 7, 2014·PloS One·Rob Hooft van HuijsduijnenTimothy N C Wells
Jan 28, 2014·PloS One·W Keith MiskiminsJoon Young Choi
Mar 5, 2014·Drug Design, Development and Therapy·Dongshan ZhangZheng Dong
Jun 15, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Katherine L CookRobert Clarke
Apr 11, 2015·Annals of Medical and Health Sciences Research·A K Das
Oct 19, 2016·Nature Reviews. Clinical Oncology·Giampaolo BianchiniLuca Gianni

❮ Previous
Next ❯

Citations

Jun 11, 2021·Journal of the American Chemical Society·Nicholas ToupinJeremy J Kodanko

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Breast Cancer: Chemo-Resistance

Some cancers are difficult to treat and aggressive including the "triple-negative" breast cancer. This type of cancer is chemoresistant even before chemotherapy begins. Here are the latest discoveries chemo-resistance in breast cancer.

Related Papers

La Vie médicale
R ARDAILLOU
West African Pharmacist
J A BERRY
Clinics in Dermatology
J S Willoughby, N H Shear
Indian Medical Journal
M SENSARMA
Journal of Tropical Pediatrics
G J Ebrahim
© 2021 Meta ULC. All rights reserved